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  1. To assess the prognostic role of coronary collaterals in patients with type 2 diabetes mellitus (T2DM) after successful percutaneous coronary intervention (PCI) for chronic total occlusion (CTO).

    Authors: Zhen Kun Yang, Ying Shen, Yang Dai, Xiao Qun Wang, Jian Hu, Feng Hua Ding, Rui Yan Zhang, Lin Lu and Wei Feng Shen
    Citation: Cardiovascular Diabetology 2020 19:59
    Content type: Original investigation Published on:

  2. Glucagon-like peptide-1 (GLP-1) induces diuresis and natriuresis. Previously we have shown that GLP-1 activates afferent renal nerve to increase efferent renal sympathetic nerve activity that negates the diure...

    Authors: Kenichi Katsurada, Shyam S. Nandi, Hong Zheng, Xuefei Liu, Neeru M. Sharma and Kaushik P. Patel
    Citation: Cardiovascular Diabetology 2020 19:57
    Content type: Original investigation Published on:

  3. The intracellular ROCK signaling pathway is an important modulator of blood pressure and of cardiovascular and renal remodeling when Rho-kinase activity is increased. Besides, in preclinical models of diabetes...

    Authors: Maria Paz Ocaranza, Patricio Valderas, Jackeline Moya, Luigi Gabrielli, Iván Godoy, Samuel Córdova, Paul Mac Nab, Lorena García, Luis Farías and Jorge E. Jalil
    Citation: Cardiovascular Diabetology 2020 19:56
    Content type: Original investigation Published on:

  6. The triglyceride-glucose (TyG) index is a marker of insulin resistance (IR) and has been associated with various metabolic syndromes, cardiovascular diseases, and cerebrovascular diseases. However, limited inf...

    Authors: Ki-Woong Nam, Hyung-Min Kwon, Han-Yeong Jeong, Jin-Ho Park, Hyuktae Kwon and Su-Min Jeong
    Citation: Cardiovascular Diabetology 2020 19:53
    Content type: Original investigation Published on:

  7. The microvascular effects of obesity should be considered in diabetic individuals for elucidating underlying mechanisms and developing targeted therapies. This study aims to determine the effect of obesity on ...

    Authors: Li Jiang, Ke Shi, Ying-kun Guo, Yan Ren, Zhen-lin Li, Chun-chao Xia, Lei Li, Xi Liu, Lin-jun Xie, Yue Gao, Meng-ting Shen, Ming-yan Deng and Zhi-gang Yang
    Citation: Cardiovascular Diabetology 2020 19:52
    Content type: Original investigation Published on:

  8. Despite the known association between non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD), whether NAFLD predicts future CVD events, especially CVD mortality, remains uncertain. We evalu...

    Authors: Jun Hyung Kim, Jin Sil Moon, Seok Joon Byun, Jun Hyeok Lee, Dae Ryong Kang, Ki Chul Sung, Jang Young Kim and Ji Hye Huh
    Citation: Cardiovascular Diabetology 2020 19:51
    Content type: Original investigation Published on:

  9. The prognostic importance of an increased visit-to-visit blood pressure variability (BP-VVV) for the future development of micro- and macrovascular complications in type 2 diabetes has been scarcely investigat...

    Authors: Claudia R. L. Cardoso, Nathalie C. Leite and Gil F. Salles
    Citation: Cardiovascular Diabetology 2020 19:50
    Content type: Original investigation Published on:

  10. Although more than one-third of the patients with acute heart failure (AHF) have diabetes mellitus (DM), it is unclear if DM has an adverse impact on clinical outcomes. This study compared the outcomes in pati...

    Authors: Min Gyu Kong, Se Yong Jang, Jieun Jang, Hyun-Jai Cho, Sangjun Lee, Sang Eun Lee, Kye Hun Kim, Byung-Su Yoo, Seok-Min Kang, Sang Hong Baek, Dong-Ju Choi, Eun-Seok Jeon, Jae-Joong Kim, Myeong-Chan Cho, Shung Chull Chae, Byung-Hee Oh…
    Citation: Cardiovascular Diabetology 2020 19:49
    Content type: Original investigation Published on:

  11. Exenatide, a glucagon like peptide 1 analog, has been suggested to reduce the cardiovascular disease risk factors, such as body weight, blood pressure and subclinical atherosclerosis in patients with type 2 di...

    Authors: Jie Zhang, Tong-Zhang Xian, Ming-Xiao Wu, Chen Li, Qi Pan and Li-Xin Guo
    Citation: Cardiovascular Diabetology 2020 19:48
    Content type: Original investigation Published on:

  12. The 5th Cardiovascular Outcome Trial (CVOT) Summit was held in Munich on October 24th–25th, 2019. As in previous years, this summit served as a reference meeting for in-depth discussions on the topic of recent...

    Authors: Oliver Schnell, Eberhard Standl, Xavier Cos, Hiddo JL Heerspink, Baruch Itzhak, Nebojsa Lalic, Michael Nauck and Antonio Ceriello
    Citation: Cardiovascular Diabetology 2020 19:47
    Content type: Commentary Published on:

  13. The clear evidence of cardiovascular benefits in cardiovascular outcome trials of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in type 2 diabetes might suggest an effect on atherosclerotic plaque vulnera...

    Authors: Valentina Spigoni, Federica Fantuzzi, Cecilia Carubbi, Giulia Pozzi, Elena Masselli, Giuliana Gobbi, Anna Solini, Riccardo C. Bonadonna and Alessandra Dei Cas
    Citation: Cardiovascular Diabetology 2020 19:46
    Content type: Original investigation Published on:

  14. Elevation in small dense low-density lipoprotein (sdLDL) is common in patients with diabetes mellitus (DM), which has already been reported to be associated with incidence of coronary artery disease (CAD). The...

    Authors: Jing-Lu Jin, Hui-Wen Zhang, Ye-Xuan Cao, Hui-Hui Liu, Qi Hua, Yan-Fang Li, Yan Zhang, Na-Qiong Wu, Cheng-Gang Zhu, Rui-Xia Xu, Ying Gao, Xiao-Lin Li, Chuan-Jue Cui, Geng Liu, Jing Sun, Qian Dong…
    Citation: Cardiovascular Diabetology 2020 19:45
    Content type: Original investigation Published on:

  15. Growing evidences shows that fasting glucose target should be different according to their health condition in older adults with diabetes. However, there are limited data regarding the relationship between fas...

    Authors: Ji Hyun Lee, Kyungdo Han and Ji Hye Huh
    Citation: Cardiovascular Diabetology 2020 19:44
    Content type: Original investigation Published on:

  16. Microangiopathy in type 2 diabetes (T2D) is associated with cardiovascular disease (CVD), but most relevant studies were performed > 10 years ago. CVD risk factor management has since improved. The aim of this...

    Authors: Jocelyn J. Drinkwater, Timothy M. E. Davis, Valentina Hellbusch, Angus W. Turner, David G. Bruce and Wendy A. Davis
    Citation: Cardiovascular Diabetology 2020 19:43
    Content type: Original investigation Published on:

  17. Stress cardiovascular magnetic resonance (CMR) to screen for silent myocardial ischaemia in asymptomatic high risk patients with type 2 diabetes mellitus (DM) has never been performed, and its effectiveness is...

    Authors: Ming-Yen Ng, Wenli Zhou, Varut Vardhanabhuti, Chi-Ho Lee, Esther Yee Tak Yu, Eric Yuk Fai Wan, Kit Chan, Andrew T. Yan, Tai-Pang Ip, Kai-Hang Yiu and Bernd J. Wintersperger
    Citation: Cardiovascular Diabetology 2020 19:42
    Content type: Original investigation Published on:

  18. To assess the impact of changes in different glucose tolerance states on risk of incident cardiovascular disease (CVD)/coronary heart disease (CHD).

    Authors: Maryam Kabootari, Mitra Hasheminia, Fereidoun Azizi, Mohammadhassan Mirbolouk and Farzad Hadaegh
    Citation: Cardiovascular Diabetology 2020 19:41
    Content type: Original investigation Published on:

  19. Clinical and basic investigations have indicated a significant association between circulating growth differentiation factor 15 (GDF15) and cardiovascular disease; however, the relationship between GDF15 and l...

    Authors: Xingxing He, Jiaorong Su, Xiaojing Ma, Wei Lu, Wei Zhu, Yufei Wang, Yuqian Bao and Jian Zhou
    Citation: Cardiovascular Diabetology 2020 19:40
    Content type: Original investigation Published on:

  20. Although studies have shown that waist circumference (WC) is positively associated with an increased risk of cardiovascular diseases among the normal population, few studies have investigated WC in patients wi...

    Authors: Zhenhua Xing, Zhenyu Peng, Xiaopu Wang, Zhaowei Zhu, Junyu Pei, Xinqun Hu and Xiangping Chai
    Citation: Cardiovascular Diabetology 2020 19:39
    Content type: Original investigation Published on:

  21. Left ventricular ejection fraction (LVEF) trajectories and functional recovery with current heart failure (HF) management is increasingly recognized. Type 2 diabetes mellitus (T2D) leads to a worse prognosis i...

    Authors: María Teresa Julián, Núria Alonso, Josep Lupón, Giovana Gavidia-Bovadilla, Elena Ferrer, Marta de Antonio, Jorge López-Ayerbe, Mar Domingo, Evelyn Santiago-Vacas, Elisabet Zamora, Pau Codina, Pedro Moliner, Julio Núñez, Javier Santesmases, Manel Puig-Domingo and Antoni Bayes-Genis
    Citation: Cardiovascular Diabetology 2020 19:38
    Content type: Original investigation Published on:

  22. The prevalence of patients with concomitant cardiovascular disease and diabetes mellitus (DM) is increasing rapidly. We aimed to compare the effectiveness of current cardiac rehabilitation (CR) programs across...

    Authors: Prisca Eser, Thimo Marcin, Eva Prescott, Leonie F. Prins, Evelien Kolkman, Wendy Bruins, Astrid E. van der Velde, Carlos Peña-Gil, Marie-Christine Iliou, Diego Ardissino, Uwe Zeymer, Esther P. Meindersma, Arnoud. W. J. Van’tHof, Ed P. de Kluiver, Markus Laimer and Matthias Wilhelm
    Citation: Cardiovascular Diabetology 2020 19:37
    Content type: Original investigation Published on:

  23. The present cohort study aims to examine the relationship between fibrinogen (Fib) levels and glucose metabolism [fasting blood glucose (FBG) and hemoglobin A1c (HbA1c)] and investigate the impact of high Fib ...

    Authors: Shuo-Lin Liu, Na-Qiong Wu, Hui-Wei Shi, Qian Dong, Qiu-ting Dong, Ying Gao, Yuan-Lin Guo and Jian-Jun Li
    Citation: Cardiovascular Diabetology 2020 19:36
    Content type: Original investigation Published on:

  24. Cardiovascular outcome trials (CVOTs) have demonstrated a significant reduction of major adverse cardiovascular events (MACE) in patients with type 2 diabetes (T2D) treated by SGLT-2 inhibitors. This holds tru...

    Authors: Dario Giugliano, Luca De Nicola, Maria Ida Maiorino, Giuseppe Bellastella, Carlo Garofalo, Paolo Chiodini, Antonio Ceriello and Katherine Esposito
    Citation: Cardiovascular Diabetology 2020 19:35
    Content type: Commentary Published on:

  25. Data on the relationship between the triglyceride glucose (TyG) index and coronary artery calcification (CAC) progression is limited. This longitudinal study evaluated the association of TyG index with CAC pro...

    Authors: Ki-Bum Won, Eun Ji Park, Donghee Han, Ji Hyun Lee, Su-Yeon Choi, Eun Ju Chun, Sung Hak Park, Hae-Won Han, Jidong Sung, Hae Ok Jung and Hyuk-Jae Chang
    Citation: Cardiovascular Diabetology 2020 19:34
    Content type: Original investigation Published on:

  26. The proprotein convertase subtilisin/kexin type 9 (PCSK9) acts via a canonical pathway to regulate circulating low-density lipoprotein-cholesterol (LDL-C) via degradation of the LDL receptor (LDLR) on the live...

    Authors: Ying Tang, Sheng-Lan Li, Jia-Hui Hu, Kai-Jun Sun, Lei-Ling Liu and Dan-Yan Xu
    Citation: Cardiovascular Diabetology 2020 19:33
    Content type: Review Published on:

  27. Biomarkers may contribute to our understanding of the pathophysiology of various diseases. Type 2 diabetes (T2D) and coronary heart disease (CHD) share many clinical and lifestyle risk factors and several biom...

    Authors: Cornelia Huth, Alina Bauer, Astrid Zierer, Julie Sudduth-Klinger, Christa Meisinger, Michael Roden, Annette Peters, Wolfgang Koenig, Christian Herder and Barbara Thorand
    Citation: Cardiovascular Diabetology 2020 19:32
    Content type: Original investigation Published on:

  28. The triglyceride glucose (TyG) index, a simple surrogate estimate of insulin resistance, has been demonstrated to predict cardiovascular (CV) disease morbidity and mortality in the general population and many ...

    Authors: Xiaoteng Ma, Lisha Dong, Qiaoyu Shao, Yujing Cheng, Sai Lv, Yan Sun, Hua Shen, Zhijian Wang, Yujie Zhou and Xiaoli Liu
    Citation: Cardiovascular Diabetology 2020 19:31
    Content type: Original investigation Published on:

  29. Studies specifically examining the association between glycated hemoglobin A1c (HbA1c) levels and ischemic stroke/systemic thromboembolism (IS/SE) risk in atrial fibrillation (AF) patients are limited. Here, w...

    Authors: Yi-Hsin Chan, Chi Chuang, Cze-Ci Chan, Hsin-Fu Lee, Ya-Chi Huang, Yu-Tung Huang, Shang-Hung Chang, Chun-Li Wang, Tze-Fan Chao, Chi-Tai Kuo, Yung-Hsin Yeh and Shih-Ann Chen
    Citation: Cardiovascular Diabetology 2020 19:30
    Content type: Original investigation Published on:

  30. The study regarding load-independent effects of empagliflozin contribute to improved cardiac function in experimental heart failure with reduced ejection fraction is very interesting. But there are a few thing...

    Authors: Bo Liang, Yu-Xiu Zhao and Ning Gu
    Citation: Cardiovascular Diabetology 2020 19:29
    Content type: Commentary Published on:

  31. The Action to Control Cardiovascular Risk in Diabetes (ACCORD)-Lipid study found no evidence of a beneficial effect of statin-fibrate combined treatment, compared to statins alone, on cardiovascular outcomes a...

    Authors: Lin Zhu, Andrew Hayen and Katy J. L. Bell
    Citation: Cardiovascular Diabetology 2020 19:28
    Content type: Original investigation Published on:

  32. High soluble suppression of tumorigenicity-2 (sST2) is a marker of poor prognosis in chronic inflammatory conditions. ST2 and its ligand interleukin (IL)-33 are elevated in adipose tissue of obese individuals....

    Authors: Svitlana Demyanets, Christoph Kaun, Alexandra Kaider, Walter Speidl, Manfred Prager, Stanislav Oravec, Philipp Hohensinner, Johann Wojta and Gersina Rega-Kaun
    Citation: Cardiovascular Diabetology 2020 19:26
    Content type: Original investigation Published on:

  33. The low cost of thiazolidinediones makes them a potentially valuable therapeutic option for the > 300 million economically disadvantaged persons worldwide with type 2 diabetes mellitus. Differential selectivit...

    Authors: Charles E. Leonard, Colleen M. Brensinger, Ghadeer K. Dawwas, Rajat Deo, Warren B. Bilker, Samantha E. Soprano, Neil Dhopeshwarkar, James H. Flory, Zachary T. Bloomgarden, Joshua J. Gagne, Christina L. Aquilante, Stephen E. Kimmel and Sean Hennessy
    Citation: Cardiovascular Diabetology 2020 19:25
    Content type: Original investigation Published on:

  34. Obesity, hypertension and prediabetes contribute greatly to coronary artery disease, heart failure and vascular events, and are the leading cause of mortality and morbidity in developed societies. Salt sensiti...

    Authors: Vijayakumar Sukumaran, Hirotsugu Tsuchimochi, Takashi Sonobe, Mark T. Waddingham, Mikiyasu Shirai and James T. Pearson
    Citation: Cardiovascular Diabetology 2020 19:24
    Content type: Original investigation Published on:

  35. Many studies have reported the predictive value of the atherogenic index of plasma (AIP) in the progression of atherosclerosis and the prognosis of percutaneous coronary intervention (PCI). However, the utilit...

    Authors: Zheng Qin, Kuo Zhou, Yueping Li, Wanjun Cheng, Zhijian Wang, Jianlong Wang, Fei Gao, Lixia Yang, Yingkai Xu, Yafeng Wu, Hua He and Yujie Zhou
    Citation: Cardiovascular Diabetology 2020 19:23
    Content type: Original investigation Published on:

  36. Little is known about whether mitochondria 8-hydroxy-2′-deoxyguanosine (8-OHdG), a biomarker of mitochondrial DNA (mtDNA) oxidative damage, contributes to the development of coronary artery disease (CAD) in di...

    Authors: Xue-bin Wang, Ning-hua Cui, Xia’nan Liu and Xin Liu
    Citation: Cardiovascular Diabetology 2020 19:22
    Content type: Original investigation Published on:

  37. In the secondary prevention of cardiovascular (CV) disease in patients with diabetes, an optimal level of HbA1c, the most widely-used glycemic control indicator, for favorable clinical consequences still remai...

    Authors: Takehiro Funamizu, Hiroshi Iwata, Yuya Nishida, Katsutoshi Miyosawa, Shinichiro Doi, Yuichi Chikata, Jun Shitara, Hirohisa Endo, Hideki Wada, Ryo Naito, Manabu Ogita, Tomotaka Dohi, Takatoshi Kasai, Shinya Okazaki, Kikuo Isoda, Katsumi Miyauchi…
    Citation: Cardiovascular Diabetology 2020 19:21
    Content type: Original investigation Published on:

  38. Empagliflozin (empa), a selective sodium–glucose cotransporter (SGLT)2 inhibitor, reduced cardiovascular mortality and hospitalization for heart failure in patients with type 2 diabetes at high cardiovascular ...

    Authors: Sin-Hee Park, Muhammad Akmal Farooq, Sébastien Gaertner, Christophe Bruckert, Abdul Wahid Qureshi, Hyun-Ho Lee, Djamel Benrahla, Brigitte Pollet, Dominique Stephan, Patrick Ohlmann, Jean-Marc Lessinger, Eric Mayoux, Cyril Auger, Olivier Morel and Valérie B. Schini-Kerth
    Citation: Cardiovascular Diabetology 2020 19:19
    Content type: Original investigation Published on:

  39. Diabetes mellitus is characterized by chronic vascular inflammation leading to pathological expression of the thrombogenic full length (fl) tissue factor (TF) and its isoform alternatively-spliced (as) TF. Blo...

    Authors: Marco Witkowski, Mario Witkowski, Mona Saffarzadeh, Julian Friebel, Termeh Tabaraie, Loc Ta Bao, Aritra Chakraborty, Andrea Dörner, Bernd Stratmann, Diethelm Tschoepe, Samantha J. Winter, Andreas Krueger, Wolfram Ruf, Ulf Landmesser and Ursula Rauch
    Citation: Cardiovascular Diabetology 2020 19:20
    Content type: Original investigation Published on:

  40. Sodium glucose cotransporter 2 (SGLT2) inhibitors have shown greater reductions of cardiovascular event risks than dipeptidyl peptidase-4 (DPP4) inhibitors, whereby possible mechanisms may involve the better p...

    Authors: Shih-Chieh Shao, Kai-Cheng Chang, Swu-Jane Lin, Rong-Nan Chien, Ming-Jui Hung, Yuk-Ying Chan, Yea-Huei Kao Yang and Edward Chia-Cheng Lai
    Citation: Cardiovascular Diabetology 2020 19:17
    Content type: Original investigation Published on:

  41. Cardiac adipose tissue may have local paracrine effects on epicardial arteries and the underlying myocardium, promoting calcification and affecting myocardial microcirculation. We explored whether the total am...

    Authors: Emilie H. Zobel, Regitse Højgaard Christensen, Signe A. Winther, Philip Hasbak, Christian Stevns Hansen, Bernt J. von Scholten, Lene Holmvang, Andreas Kjaer, Peter Rossing and Tine W. Hansen
    Citation: Cardiovascular Diabetology 2020 19:16
    Content type: Original investigation Published on:

  42. Heart-type fatty acid-binding protein (H-FABP) is a novel marker of myocardial injury and has been reported to be associated with cardiovascular diseases (CVD) including patients with diabetes mellitus (DM). U...

    Authors: Hui-Wen Zhang, Jing-Lu Jin, Ye-Xuan Cao, Hui-Hui Liu, Yan Zhang, Yuan-Lin Guo, Na-Qiong Wu, Ying Gao, Rui-Xia Xu, Qi Hua, Yan-Fang Li, Chuan-Jue Cui, Geng Liu, Qian Dong, Jing Sun and Jian-Jun Li
    Citation: Cardiovascular Diabetology 2020 19:15
    Content type: Original investigation Published on:

  43. Mixed dyslipidemia [elevated non-high-density lipoprotein cholesterol (non-HDL-C) and triglycerides (TGs), and decreased HDL-C] is common in type 2 diabetes mellitus (T2DM) and is associated with increased car...

    Authors: Helen M. Colhoun, Lawrence A. Leiter, Dirk Müller-Wieland, Bertrand Cariou, Kausik K. Ray, Francisco J. Tinahones, Catherine Domenger, Alexia Letierce, Marc Israel, Rita Samuel and Stefano Del Prato
    Citation: Cardiovascular Diabetology 2020 19:14
    Content type: Original investigation Published on:

  44. Sodium–glucose linked cotransporter-2 (SGLT2) inhibitors reduce the likelihood of hospitalization for heart failure and cardiovascular death in both diabetic and non-diabetic individuals with reduced ejection ...

    Authors: Kim A. Connelly, Yanling Zhang, Jean-François Desjardins, Linda Nghiem, Aylin Visram, Sri N. Batchu, Verra G. Yerra, Golam Kabir, Kerri Thai, Andrew Advani and Richard E. Gilbert
    Citation: Cardiovascular Diabetology 2020 19:13
    Content type: Original investigation Published on:

  45. Type 2 diabetes increases the risk of coronary heart disease (CHD), yet the mechanisms involved remain poorly described. Polygenic risk scores (PRS) provide an opportunity to understand risk factors since they...

    Authors: Tianyuan Lu, Vincenzo Forgetta, Oriana H. Y. Yu, Lauren Mokry, Madeline Gregory, George Thanassoulis, Celia M. T. Greenwood and J. Brent Richards
    Citation: Cardiovascular Diabetology 2020 19:12
    Content type: Original investigation Published on:

  46. Insulin resistance may contribute to aortic stiffening that leads to end-organ damage. We examined the cross-sectional association and prospective association of insulin resistance and aortic stiffness in olde...

    Authors: Anna K. Poon, Michelle L. Meyer, Hirofumi Tanaka, Elizabeth Selvin, James Pankow, Donglin Zeng, Laura Loehr, Joshua W. Knowles, Wayne Rosamond and Gerardo Heiss
    Citation: Cardiovascular Diabetology 2020 19:11
    Content type: Original investigation Published on:

  47. Although a variety of antidiabetic drugs have significant protective action on the cardiovascular system, it is still unclear which antidiabetic drugs can improve ventricular remodeling and fundamentally delay...

    Authors: Da-Peng Zhang, Li Xu, Le-Feng Wang, Hong-Jiang Wang and Feng Jiang
    Citation: Cardiovascular Diabetology 2020 19:10
    Content type: Original investigation Published on:

  48. To examine the incidence of atrial fibrillation in individuals with type 2 diabetes compared with age- and sex-matched controls from the general population and its variation in relation to glycaemic control an...

    Authors: Shilan Seyed Ahmadi, Ann-Marie Svensson, Aldina Pivodic, Annika Rosengren and Marcus Lind
    Citation: Cardiovascular Diabetology 2020 19:9
    Content type: Original investigation Published on:

  50. Diabetes mellitus type 2 (DM2) is a risk factor for developing heart failure but there is no specific therapy for diabetic heart disease. Sodium glucose transporter 2 inhibitors (SGLT2I) are recently developed...

    Authors: M. Arow, M. Waldman, D. Yadin, V. Nudelman, A. Shainberg, N. G. Abraham, D. Freimark, R. Kornowski, D. Aravot, E. Hochhauser and M. Arad
    Citation: Cardiovascular Diabetology 2020 19:7
    Content type: Original investigation Published on:
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Cardiovascular Diabetology

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