Table 2 MR assessing the causal association between potential proteins and causal risk factors for outcomes
Protein | Outcome | β (95% CI) | SE | P value |
|---|---|---|---|---|
CTSA | HDL-C | 0.11 (0.07, 0.15) | 0.020 | 1.16e-08 |
SHBG | 0.51 (0.47, 0.54) | 0.017 | 6.72e-188 | |
DNAJB9 | SHBG | -0.12 (-0.15, -0.1) | 0.013 | 2.09e-21 |
FST | alcohol consumption | -0.2 (-0.24, -0.16) | 0.021 | 1.31e-21 |
SHBG | -0.46 (-0.5, -0.41) | 0.022 | 3.14e-99 | |
IGFBP1 | alcohol consumption | -0.17 (-0.21, -0.13) | 0.019 | 3.31e-19 |
SHBG | -0.4 (-0.44, -0.36) | 0.019 | 1.20e-95 | |
IL12RB1 | SHBG | 0.02 (0.02, 0.03) | 0.004 | 4.17e-09 |
IL6R | SHBG | 0.02 (0.01, 0.03) | 0.004 | 4.49e-08 |
RSPO3 | HDL-C | -0.07 (-0.1, -0.05) | 0.013 | 5.76e-09 |