Table 1 MR assessing the causal association between risk factors and primary outcomes
Exposure | Outcome | SNPs | IVW | Weighted median | Weighted mode | MR-Egger regression | Q | Q_ P value | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
β (95% CI) | P | β | P | β | P | intercept | P | |||||
alcohol consumption | Pancreas volume | 3 | 0.359 (0.154, 0.564) | 6.10e-04 | 0.395 | 5.05e-02 | 0.487 | 1.96e-01 | 0.007 | 0.845 | 0.671 | 7.15e-01 |
HDL-C | Liver volume | 84 | -0.129 (-0.212, -0.046) | 2.37e-03 | -0.069 | 3.21e-02 | -0.065 | 3.45e-02 | -0.004 | 0.216 | 384.565 | 2.39e-40 |
HOMA-B | Liver fat | 3 | -0.056 (-0.07, -0.043) | 2.05e-15 | -0.057 | 7.01e-01 | -0.058 | 7.77e-01 | -0.001 | 0.972 | 0.005 | 9.97e-01 |
NAFLD | Liver fat | 2 | 0.395 (0.329, 0.461) | 1.31e-31 | … | … | … | … | … | … | 6.666 | 9.83e-03 |
Pancreas fat | 2 | -0.043 (-0.059, -0.028) | 7.12e-08 | … | … | … | … | … | … | 0.309 | 5.78e-01 | |
SHBG | Liver fat | 150 | -0.205 (-0.319, -0.091) | 4.28e-04 | -0.113 | 5.70e-03 | -0.073 | 1.31e-01 | -0.007 | 0.060 | 1161.315 | 2.79e-156 |
Liver volume | 150 | -0.139 (-0.221, -0.057) | 9.29e-04 | -0.064 | 5.85e-02 | -0.027 | 4.02e-01 | -0.003 | 0.292 | 728.913 | 3.26e-77 | |
smoking initiation | Liver volume | 72 | 0.198 (0.11, 0.285) | 9.56e-06 | 0.125 | 1.85e-02 | 0.096 | 3.32e-01 | -0.007 | 0.208 | 111.529 | 1.52e-03 |
Pancreas fat | 72 | 0.137 (0.052, 0.222) | 1.66e-03 | 0.129 | 4.05e-02 | 0.161 | 3.00e-01 | -0.001 | 0.865 | 71.421 | 4.64e-01 | |
VAT volume | 72 | 0.166 (0.087, 0.245) | 3.78e-05 | 0.121 | 2.26e-02 | 0.053 | 5.99e-01 | -0.002 | 0.770 | 101.869 | 9.57e-03 | |
time spent watching television | Liver fat | 52 | 0.407 (0.218, 0.596) | 2.40e-05 | 0.345 | 1.15e-02 | 0.433 | 1.75e-01 | -0.006 | 0.319 | 55.483 | 3.10e-01 |
Pancreas fat | 52 | 0.491 (0.251, 0.732) | 6.26e-05 | 0.526 | 3.22e-04 | 0.632 | 3.84e-02 | -0.008 | 0.310 | 73.890 | 1.97e-02 | |
VAT volume | 52 | 0.656 (0.486, 0.826) | 3.61e-14 | 0.632 | 1.22e-07 | 0.789 | 2.32e-02 | -0.007 | 0.202 | 61.121 | 1.57e-01 | |