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Fig. 3 | Cardiovascular Diabetology

Fig. 3

From: Clinically relevant plasma proteome for adiposity depots: evidence from systematic mendelian randomization and colocalization analyses

Fig. 3

Mediating role of risk factors in the causal association between identified proteins and outcomes. A), Two-step MR analysis framework. β1 effect of exposure on mediator, β2 effect of mediator on outcome, β3 effect of exposure on outcome. B), MR estimates for the mediation effect of each mediator and the proportion mediated by each mediator. The squares and bars represent the mediated proportions (95% CIs)

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Cardiovascular Diabetology

ISSN: 1475-2840