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Table 3 Prioritization of causal inflammation biomarkers of heart failure using the MR-BMA method

From: Sodium-glucose cotransporter 2 inhibitors, inflammation, and heart failure: a two-sample Mendelian randomization study

Inflammation biomarker

MIP

MACE

Empirical

P-value

FDR adjusted

P value

CXCL10

0.861

0.224

0.0422

0.0844

LIF

0.203

−0.018

0.9006

0.9006

  1. Inflammation biomarkers ranked by the marginal inclusion probability in the MR-BMA analysis after model diagnostics. Empirical P-values were computed using 10,000 permutations. The prior probability and prior variance used in the MR-BMA analysis were 0.1 and 0.5
  2. MIP marginal inclusion probability, MACE model-averaged causal effect, CXCL10 C-X-C motif chemokine 10, LIF Leukemia inhibitory factor
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Cardiovascular Diabetology

ISSN: 1475-2840