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Table 1 MR estimates of the effect of SGLT2 inhibition on heart failure

From: Sodium-glucose cotransporter 2 inhibitors, inflammation, and heart failure: a two-sample Mendelian randomization study

Method

Number of SNPs

OR (95% CI)

P value

Q statistic

P-heterogeneity

Egger-intercept

P-intercept

Inverse variance weighted

14

0.42(0.30–0.59)

0.0000

9.5282

0.7320

  

MR egger

14

0.36(0.09–1.48)

0.1814

9.4818

0.6613

0.0021

0.8331

Simple mode

14

0.47(0.23–0.96)

0.0590

    

Weighted median

14

0.46(0.29–0.72)

0.0007

    

Weighted mode

14

0.44(0.23–0.83)

0.0242

    

MR-PRESSO

14

0.42(0.31–0.56)

0.0000

10.6687

0.8170

  
  1. The heterogeneity test in the IVW methods was performed using Cochran’s Q statistic and the global test for the MR-PRESSO method. P < 0.05 was considered significant
  2. OR Odds ratio, CI 95% confidence interval, IVW inverse–variance weighted, P-heterogeneity P value for heterogeneity test, P-intercept P value for the intercept of MR-Egger regression
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Cardiovascular Diabetology

ISSN: 1475-2840