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Fig. 11 | Cardiovascular Diabetology

Fig. 11

From: Circ_005077 accelerates myocardial lipotoxicity induced by high-fat diet via CyPA/p47PHOX mediated ferroptosis

Fig. 11

Circ_005077 regulated ferroptosis of myocardial tissue in vivo. AAV9-OE-circ_005077, AAV9-OE-NC, AAV9-SH-circ_005077, and AAV9-SH-NC were injected individually through the tail vein. (A) Ultrastructure of the mitochondria and sarcomere using TEM (5,000×, upper row and magnified views at 10,000, lower row) (B, C) Representative immunohistochemical (IHC) staining of the ferroptosis indicator TFRC, ACSL4, COX2, FTH1 and GPX4 in myocardial tissue (Original magnification: 400×) and quantification of IHC analysis. AAV9: adeno-associated virus-9. Per group, n = 6. Data were presented as the normalized mean ± SD.*P < 0.05; **P < 0.01; ***P < 0.001

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Cardiovascular Diabetology

ISSN: 1475-2840