Table 2 Subgroup analysis of the primary outcome
Subgroup | Studies (N) | Participants (N) | RR (95% CI) | P-value | I-squared (%) |
|---|---|---|---|---|---|
Age | |||||
≥ 60 | 3 | 2,656 | 1.43 (0.72, 2.82) | 0.305 | 80.1 |
< 60 | 5 | 7,025 | 1.59 (1.26, 2.00) | < 0.001 | 51.6 |
Study design | |||||
Retrospective | 7 | 7,325 | 1.56 (1.28, 1.90) | < 0.001 | 66.4 |
Prospective | 1 | 2,356 | 1.53 (1.10, 2.12) | 0.011 | 0.0 |
Sample size | |||||
≥ 1,000 | 5 | 8,004 | 1.71 (1.31, 2.23) | < 0.001 | 69.4 |
< 1,000 | 3 | 1,677 | 1.25 (0.51, 3.07) | 0.628 | 61.6 |
Duration of follow-up | |||||
≥ 24 | 6 | 8,408 | 1.66 (1.25, 2.20) | 0.001 | 69.9 |
< 24 | 2 | 1,273 | 1.56 (0.85, 2.87) | 0.150 | 43.0 |
LDL-C | |||||
≥ 1.8 | 7 | 8,348 | 1.51 (1.27–1.81) | < 0.001 | 64.3 |
< 1.8 | 1 | 1,133 | 2.01 (1.09–3.72) | 0.026 | 0.0 |