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Fig. 1 | Cardiovascular Diabetology

Fig. 1

From: Persistent epigenetic signals propel a senescence-associated secretory phenotype and trained innate immunity in CD34+ hematopoietic stem cells from diabetic patients

Fig. 1

Schematic representation of the study. A UCB-derived CD34+ were expanded in HG conditions for 20 days. Afterward, CD34+HSPCs were phenotypically and epigenetically characterized before and after monocyte differentiation. The results were finally validated in BM-derived CD34+HSPCs from CAD and CAD-T2DM patients (B). UCB, umbilical cord blood; BM, bone marrow; HSPCs, hematopoietic stem/progenitor cells; NG, normal-glucose; HG, high-glucose

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Cardiovascular Diabetology

ISSN: 1475-2840