The neutrophil-to-lymphocyte ratio is associated with all-cause and cardiovascular mortality among individuals with hypertension

Table 3 Subgroup analysis of the associations between NLR and mortality among hypertension

Characteristics	All-cause mortality			P interaction	Cardiovascular mortality			P interaction
	Lower NLR	Higher NLR			Lower NLR	Higher NLR
	Lower NLR	HR (95% CI)	P value		Lower NLR	HR (95% CI)	P value
Age				0.3528				0.6377
< 65	Ref	2.45 (1.51,3.96)	0.0003		Ref	3.34 (1.24, 8.99)	0.0172
≥ 65	Ref	1.89 (1.50, 2.39)	< 0.0001		Ref	2.61 (1.69, 4.02)	< 0.0001
Sex				0.7958				0.5632
Male	Ref	1.87 (1.4,2.44)	< 0.0001		Ref	3.21 (1.94,5.33)	< 0.0001
Female	Ref	1.96 (1.40, 2.76)	< 0.0001		Ref	3.21 (1.94,5.33)	< 0.0001
Smoking status				0.6255				0.4922
Never	Ref	1.99 (1.43,2.76)	< 0.0001		Ref	2.33 (1.34,4.06)	0.0028
Former/current	Ref	1.84 (1.40,2.41)	< 0.0001		Ref	3.17 (1.82,5.52)	< 0.0001
BMI				0.7612				0.7453
< 25	Ref	1.84 (1.40,2.41)	< 0.0001		Ref	3.56 (1.45,8.70)	0.0054
25–30	Ref	1.99 (1.36,2.92)	0.0004		Ref	3.56 (1.45,8.70)	0.0054
≥ 30	Ref	1.67 (1.18,2.37)	0.0039		Ref	2.51 (1.38,4.55)	0.0024
Diabetes				0.1582				0.1575
No	Ref	1.72 (1.33,2.23)	< 0.0001		Ref	2.26 (1.35,3.78)	0.0019
Yes	Ref	2.39 (1.66,3.45)	< 0.0001		Ref	4.08 (2.18,7.64)	< 0.0001
History of CVD				0.3115				0.1799
No	Ref	1.78 (1.34,2.38)	< 0.0001		Ref	4.08 (2.18,7.64)	< 0.0001
Yes	Ref	2.25 (1.64,3.07)	< 0.0001		Ref	3.54 (2.13,5.88)	< 0.0001

HRs were adjusted for age, sex, race, BMI, smoking status, education level, diabetes, history of CVD, HDL, LDL, TG, TC, HbA1c, and eGFR

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