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Fig. 5 | Cardiovascular Diabetology

Fig. 5

From: Protective effects of imeglimin on the development of atherosclerosis in ApoE KO mice treated with STZ

Fig. 5

a Inducible NO synthase (iNOS) expression levels were significantly lower in imeglimin-treated mice compared to untreated DM mice (control group). b, c Expression levels of cell adhesion factors such as Vcam-1 and Icam-1 were not different between control and imeglimin group. d Expression level of a macrophage marker F4/80 was significantly lower in imeglimin group compared to control group. e Expression level of CD68 was not different between control and imeglimin group. f, g Concerning plaque stability markers TIMP1 and MMP2, TIMP1 levels were not different between control and imeglimin group, but MMP2 level was significantly lower in imeglimin group compared to control group. n = 8–10. *: p < 0.05

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Cardiovascular Diabetology

ISSN: 1475-2840