Fig. 5

Score trajectory (A) and loading (B) plots of the difference in postprandial metabolite responses in liver IR compared to muscle IR using RM-ASCA + analysis. A Scores containing the predominant patterns over time for PC1 and PC2. Bootstrapped 95% confidence intervals are shown as shaded area for the scores. B Loading plots of a set of metabolites that includes those with a significant loading for PC1 and/or PC2, excluding those with a significantly different iAUC between IR phenotypes and excluding relative lipoprotein lipid composition (percentages). The loadings show the association of the scores with the metabolite responses. A positive loading indicates a positive association between the metabolite response and the score (pattern) as shown in this figure, while a negative loading indicates a negative association between the metabolite response and the score (pattern) as shown in this figure, i.e. the inverse of the depicted pattern. Bootstrapped 95% confidence intervals are shown as error bars for the loadings. Filled dots indicate p < 0.05