Fig. 1

Plasma glucose (A) and insulin (B) responses to consumption of the high-fat mixed meal in individuals with liver IR or muscle IR. Responses were defined as change from fasting (value at postprandial timepoint—fasting value), and data are shown as means with 95% confidence intervals. Differences between liver IR and muscle IR were tested using linear mixed-effects models with adjustment for age, sex, center, and BMI. Significant LSD post-hoc pairwise comparisons per timepoint are denoted with *(p < 0.05) or ***(p < 0.001)