|  |  | Weight Loss |  | Weight Gain 0–6% |  | Weight Gain ≥6% |  |  |
---|---|---|---|---|---|---|---|---|---|
Cardiovascular Risk Factor | (n = 100) |  | (n = 110) |  | (n = 120) |  | P | ||
Triglycerides (mmol/l): | Â | Â | Â | Â | Â | Â | Â | ||
 At 1-year |  | 0.90 ± 0.05 | 1.00 ± 0.05 | 0.98 ± 0.05 | 0.2 | ||||
 At 3-years |  | 0.84 ± 0.04 | 0.92 ± 0.04 | 0.98 ± 0.04 a | 0.02 | ||||
 At 5-years |  | 0.90 ± 0.05 | 1.05 ± 0.05 b | 1.11 ± 0.05 a | 0.001 | ||||
HDL cholesterol (mmol/l): | Â | Â | Â | Â | Â | Â | Â | ||
 At 1-year |  | 1.45 ± 0.04 | 1.48 ± 0.04 | 1.42 ± 0.04 | 0.44 | ||||
 At 3-years |  | 1.44 ± 0.04 | 1.46 ± 0.04 | 1.41 ± 0.04 | 0.51 | ||||
 At 5-years |  | 1.61 ± 0.05 | 1.62 ± 0.05 | 1.49 ± 0.04 c | 0.02 | ||||
LDL cholesterol (mmol/l): | Â | Â | Â | Â | Â | Â | Â | ||
 At 1-year |  | 2.56 ± 0.10 | 2.67 ± 0.10 | 2.69 ± 0.09 | 0.47 | ||||
 At 3-years |  | 2.42 ± 0.10 | 2.55 ± 0.10 | 2.56 ± 0.08 | 0.36 | ||||
 At 5-years |  | 2.26 ± 0.10 | 2.48 ± 0.09 | 2.59 ± 0.08 a | 0.01 | ||||
apoB (g/L): | Â | Â | Â | Â | Â | Â | Â | Â | |
 At 1-year |  | 0.78 ± 0.03 | 0.82 ± 0.02 | 0.81 ± 0.02 | 0.47 | ||||
 At 3-years |  | 0.72 ± 0.02 | 0.77 ± 0.02 | 0.77 ± 0.02 | 0.13 | ||||
 At 5-years |  | 0.74 ± 0.03 | 0.82 ± 0.03b | 0.84 ± 0.02a | 0.003 | ||||
Matsuda index: | Â | Â | Â | Â | Â | Â | Â | Â | |
 At 1-year |  | 6.86 ± 0.48 | 6.85 ± 0.47 | 6.92 ± 0.43 | 0.99 | ||||
 At 3-years |  | 6.96 ± 0.44 | 6.02 ± 0.38 | 5.26 ± 0.29 a | 0.0006 | ||||
 At 5-years |  | 7.28 ± 0.49 | 6.02 ± 0.38 b | 5.06 ± 0.29 a,c | < 0.0001 | ||||
HOMA-IR: | Â | Â | Â | Â | Â | Â | Â | Â | |
 At 1-year |  | 1.37 ± 0.09 | 1.35 ± 0.09 | 1.38 ± 0.08 | 0.95 | ||||
 At 3-years |  | 1.34 ± 0.09 | 1.59 ± 0.10 | 1.75 ± 0.10 a | 0.002 | ||||
 At 5-years |  | 1.21 ± 0.08 | 1.44 ± 0.09 | 1.81 ± 0.10 a,c | < 0.0001 | ||||
Fasting glucose (mmol/l): | Â | Â | Â | Â | Â | Â | Â | ||
 At 1-year |  | 4.70 ± 0.06 | 4.78 ± 0.06 | 4.83 ± 0.05 | 0.18 | ||||
 At 3-years |  | 4.64 ± 0.06 | 4.73 ± 0.06 | 4.84 ± 0.05 a | 0.01 | ||||
 At 5-years |  | 4.63 ± 0.07 | 4.74 ± 0.07 | 4.82 ± 0.06 | 0.07 | ||||
CRP (mg/L): | Â | Â | Â | Â | Â | Â | Â | Â | |
 At 1-year |  | 1.01 ± 0.14 | 1.10 ± 0.15 | 1.21 ± 0.15 | 0.55 | ||||
 At 3-years |  | 0.82 ± 0.11 | 1.01 ± 0.14 | 1.27 ± 0.15 a | 0.02 | ||||
 At 5-years |  | 0.77 ± 0.12 | 1.04 ± 0.16 | 1.34 ± 0.18 a | 0.01 |