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Table 2 Multivariable adjusted hazard ratios (aHR) for CADa events comparing assignment to intensive lifestyle intervention versus diabetes support and education control groups for each phenotype group separately

From: Intensive lifestyle intervention in type 2 diabetes and risk of incident coronary artery disease for the common haptoglobin phenotypes: the Look AHEAD study

 

DSE (reference)

ILI

Hazard ratios (HRs)

# Events/n

Person-years

# Events/n

Person-years

uHR (95% CI)

P-value

aHRb (95% CI)

P-value

Non-Hp2-2 phenotypes

198/1478

13,338.33

180/1474

13,433.02

0.90 (0.74–1.10)

0.32

0.95 (0.78–1.17)

0.66

Hp2-2 phenotype

106/767

6940.46

112/823

7391.85

0.99 (0.76–1.30)

0.96

0.89 (0.68–1.19)

0.44

  1. CAD coronary artery disease, CI confidence interval, DSE diabetes support and education, Hp haptoglobin, aHR adjusted hazard ratio, uHR unadjusted hazard ratio, ILI intensive lifestyle intervention
  2. aThe CAD event outcome is a composite of fatal and non-fatal MI, hospitalization for angina, and possible fatal CAD
  3. bModels were adjusted for age, sex, race, study site, prior history of CVD, triglycerides, systolic blood pressure, diastolic blood pressure, income (with category for missing), education, antidepressant medication use, any diabetes medication use, any anti-hypertensive medication use and any lipid medication use. After Bonferroni correction to account for multiple testing, a P-value threshold of < 0.002 (0.05 divided by 24) was used
  4. The P-value for the test of interaction between intervention and Hp phenotype for the adjusted model is 0.58
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Cardiovascular Diabetology

ISSN: 1475-2840