Table 2 Univariate and Multivariate Cox regression analysis for clinical events

Age

1.04 (1.01–1.06)

0.001

1.04 (1.01–1.08)

0.018

NYHA

1.16 (0.87–1.54)

0.310

Sex

1.44 (1.08–1.93)

0.013

1.87 (1.07–3.27)

0.027

Smoking

1.36 (0.98–1.89)

0.062

1.47 (0.88–2.47)

0.144

BMI

1.04 (1.00-1.08)

0.036

1.00 (0.95–1.06)

0.947

Atrial fibrillation

1.62 (1.20–2.18)

0.002

0.92 (0.52–1.62)

0.765

Hypertension

0.92 (0.66–1.28)

0.630

Chronic kidney disease

1.44 (0.96–2.15)

0.076

1.13 (0.60–2.12)

0.704

Hyperlipidemia

1.08 (0.80–1.45)

0.610

CHD

0.91 (0.68–1.22)

0.521

Diabetes

1.45 (1.09–1.92)

0.011

1.67 (1.07–2.61)

0.024

LDL

1.07 (0.91–1.27)

0.409

Total cholesterol

0.94 (0.83–1.06)

0.315

eGFR

0.99(0.98-1.00)

0.001

0.99 (0.98-1.00)

0.132

C-reactive protein

1.03 (1.01–1.06)

0.010

1.04 (0.99–1.07)

0.056

NT-proBNP

1.00 (1.00–1.00)

0.001

1.00 (1.00–1.00)

0.014

LVEF

0.96 (0.93–0.99)

0.007

1.01 (0.96–1.05)

0.736

LAVI

1.03 (1.00-1.05)

0.028

1.04 (0.99–1.11)

0.097

e’

0.87 (0.76–0.99)

0.047

0.86 (0.72–1.03)

0.110

E/e’

1.06 (1.01–1.11)

0.030

1.04 (0.97–1.12)

0.212

PASP

1.01 (1.00-1.03)

0.100

LVEDD

1.02 (1.00-1.05)

0.059

0.98 (0.93–1.03)

0.558

Beta-blockers

0.89 (0.67–1.19)

0.445

ACE + ARB

0.73 (0.55–0.97)

0.032

0.63 (0.39–0.99)

0.048

Diuretic

0.93 (0.70–1.24)

0.619

MCRA

0.99 (0.74–1.34)

0.968

Statins

0.74 (0.52–1.06)

0.099

0.59 (0.32–1.08)

0.089

Calcium channel blockers

0.73 (0.53–1.01)

0.054

0.80 (0.49–1.32)

0.382

Anticoagulant

1.28 (0.89–1.85)

0.180

SHR > 0.99

2.57 (1.93–3.44)

< 0.001

2.34 (1.49–3.67)

< 0.001