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Table 3 Association of plasma angiogenin with MACE

From: Association of plasma angiogenin with risk of major cardiovascular events in type 2 diabetes

Plasma angiogenin

Unadjusted Model

Multivariable Model 1

Multivariable Model 2

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

Continuous variable

(per 1 unit increment)*

3.10 (1.84–5.22)

< 0.001

2.38 (1.34–4.23)

0.003

1.90 (1.02–3.53)

0.044

Categorical variable

Lower tertile

Reference

Reference

Reference

Intermediate tertile

1.67 (0.96–2.92)

0.069

1.46 (0.83–2.58)

0.187

1.33 (0.75–2.36)

0.330

Upper tertile

2.72 (1.62–4.56)

< 0.001

1.98 (1.15–3.42)

0.014

1.63 (0.91–2.89)

0.098

  1. Cox proportional hazard regression model: time to 4-point MACE as outcome
  2. Model 1 adjusted for age, sex, ethnicity, CVD history (yes or no), smoking status (current versus others), body mass index, diabetes duration, HbA1c, mean arterial pressure, HDL-cholesterol, LDL-cholesterol, log-transformed triacylglycerol, statin and aspirin usage
  3. Model 2 additionally adjusted for baseline eGFR and log-transformed urine ACR above model 1
  4. * One NPX increment is interpreted as doubling of plasma angiogenin concentration measured by proximity extension assay
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Cardiovascular Diabetology

ISSN: 1475-2840