Table 1 Baseline clinical and biochemical characteristics in participants stratified by MACE outcome
From: Association of plasma angiogenin with risk of major cardiovascular events in type 2 diabetes
With MACE (N = 109) | Without MACE (N = 974) | P value | |
|---|---|---|---|
Plasma angiogenin (NPX, IQR) | 1.12 (0.91–1.41) | 0.95 (0.76–1.19) | < 0.001 |
Index age (years) | 56.4 ± 9.2 | 53.2 ± 10.7 | 0.001 |
Male sex (%) | 58.7 | 48.6 | 0.044 |
Ethnicity (%) | 0.003 | ||
Chinese | 35.8 | 50.9 | |
Malay | 33.9 | 21.5 | |
Asian Indian | 30.3 | 27.6 | |
Diabetes duration (years, IQR) | 7 (4–15) | 5 (3–10) | 0.001 |
Active smoker (%) | 15.7 | 9.2 | 0.032 |
ASCVD history (%) | 16.5 | 5.0 | < 0.001 |
Body mass index (kg/m2) | 28.7 ± 5.0 | 28.2 ± 5.4 | 0.387 |
HbA1c (%) | 8.1 ± 1.4 | 7.7 ± 1.3 | 0.005 |
Blood pressure (mmHg) | |||
Systolic | 140 ± 18 | 137 ± 17 | 0.047 |
Diastolic | 82 ± 9 | 80 ± 9 | 0.013 |
Mean arterial pressure | 101 ± 10 | 99 ± 11 | 0.010 |
Lipid profile (mM) | |||
HDL cholesterol | 1.24 ± 0.30 | 1.29 ± 0.36 | 0.107 |
LDL cholesterol | 2.92 ± 0.99 | 2.79 ± 0.80 | 0.189 |
Triacylglycerol (IQR) | 1.40 (1.06–1.94) | 1.35 (1.02–1.88) | 0.592 |
Baseline renal function | |||
eGFR (ml/min/1.73m2) | 91 ± 16 | 99 ± 17 | < 0.001 |
urine ACR (µg/mg, IQR) | 26 (9-120) | 15 (4–47) | < 0.001 |
High sensitivity CRP (pg/ml) | 2657 (666–5879) | 2213 (762–4974) | 0.282 |
Medication usage (%) | |||
Aspirin | 30.6 | 16.2 | < 0.001 |
Statin | 86.1 | 77.0 | 0.031 |