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Table 2 The definitions of metabolic syndrome were established according to the WHO, NCEP ATP III and IDF

From: Double diabetes—when type 1 diabetes meets type 2 diabetes: definition, pathogenesis and recognition

Criteria of metabolic syndrome

Organisation (year) (reference)

WHO (1999) [18, 19]

NCEP ATP III (2001, revised in 2005) [20, 21]

IDF (2005) [22]

Harmonised criteria provided, among others, by IDF and AHA (2009) [23]

Required

At least 1 of the following:

Not applicable

- Increased WC—values depending on ethnicity (for instance in Europeans ≥ 94 cm [men] or ≥ 80 cm [women]);—BMI > 30 kg/m2 is also acceptable

Not applicable

- Impaired fasting glucose

- Impaired glucose tolerance

- Diabetes

- IR (assessed by the HEC)

Additional

 

AND at least 2 of the following:

Any 3 of the following:

AND any 2 of the following:

Any 3 of the following:

Central obesity

- WHR > 0.9 [men] or > 0.85 [women] and/or—BMI > 30 kg/m2

- WC ≥ 102 cm (≥ 40 in) [men] or  ≥ 88 cm (≥ 35 in) [women]

Included in the required criterion

- Increased WC—values depending on ethnicity (for instance in Europeans ≥ 94 cm [men] or ≥ 80 cm [women])

HDL-C

- HDL-C < 0.9 mmol/L (< 35 mg/dL) [men] or < 1.0 mmol/L (< 39 mg/dL) [women] and/or—TG ≥ 1.7 mmol/L (≥ 150 mg/dL)

- < 1.03 mmol/L (< 40 mg/dL) [men] or  < 1.29 mmol/L (< 50 mg/dL) [women] or—pharmacologic treatment for reduced HDL-C

- < 1.03 mmol/L (< 40 mg/dL) [men] or  < 1.29 mmol/L (< 50 mg/dL) [women] or—pharmacologic treatment for reduced HDL-C

- < 1.03 mmol/L (< 40 mg/dL) [men] or  < 1.29 mmol/L (< 50 mg/dL) [women] or—pharmacologic treatment for reduced HDL-C

TG

- ≥ 1.7 mmol/L (≥ 150 mg/dL) or—pharmacologic treatment for elevated TG

- ≥ 1.7 mmol/L (≥ 150 mg/dL) or—pharmacologic treatment for elevated TG

- ≥ 1.7 mmol/L (≥ 150 mg/dL) or—pharmacologic treatment for elevated TG

Glycaemia

Included in the required criterion

- Fasting glycaemia ≥ 5.6 mmol/L (≥ 100 mg/dL) or—pharmacologic treatment for hyperglycaemia

- Fasting glycaemia ≥ 5.6 mmol/L (≥ 100 mg/dL) or—diagnosed T2D

- Fasting glycaemia ≥ 5.6 mmol/L (≥ 100 mg/dL) or—pharmacologic treatment for hyperglycaemia

Blood pressure

- BP ≥ 140/90 mmHg

- Systolic BP ≥ 130 mmHg or—diastolic BP ≥ 85 mmHg or—pharmacologic treatment for hypertension

- Systolic BP ≥ 130 mmHg or—diastolic BP ≥ 85 mmHg or—pharmacologic treatment for hypertension

- Systolic BP ≥ 130 mmHg and/or—diastolic BP ≥ 85 mmHg or pharmacologic treatment for hypertension

Other

- Urinary albumin excretion rate 20 µg/min or—ACR ≥ 30 mg/g

  1. ACR albumin-to-creatinine ratio, AHA American Heart Association, BMI body mass index, BP blood pressure, HDL-C HDL-cholesterol, HEC the hyperinsulinaemic-euglycaemic clamp, IDF International Diabetes Federation, IR insulin resistance, NCEP ATP III National Cholesterol Education Program Adult Treatment Panel III, T2D type 2 diabetes, TG triglyceride, WC waist circumference, WHO World Health Organisation, WHR waist-to-hip ratio