Table 2 Predictive performance of selected protein biomarkers for incident coronary heart disease on top of framingham risk score (FRS) components

With T2D^a

C-index

0.693 [0.563; 0.774]

0.711 [0.656; 0.810]

0.642 [0.545; 0.861]

0.667 [0.652; 0.876]

ΔC-index

-

0.017 [0.006; 0.145]

-

0.025 [-0.037; 0.142]

cfNRI

-

0.253 [0.024; 0.497]

-

0.633 [0.139; 1.075]

cfNRI_cases

-

0.038 [-0.022; 0.401]

-

0.127 [-0.373; 0.493]

cfNRI_controls

-

0.215 [0.116; 0.465]

-

0.506 [0.288; 0.796]

IDI

-

0.051 [0.014; 0.124]

-

0.017 [-0.045; 0.174]

Without T2D^b

C-index

0.700 [0.657; 0.760]

0.754 [0.729; 0.817]

0.683 [0.564; 0.769]

0.721 [0.627; 0.812]

ΔC-index

-

0.054 [0.026; 0.102]

-

0.038 [0.024; 0.133]

cfNRI

-

0.462 [0.325; 0.742]

-

0.465 [0.027; 0.741]

cfNRI_cases

-

0.087 [-0.002; 0.321]

-

0.085 [-0.312; 0.268]

cfNRI_controls

-

0.375 [0.292; 0.462]

-

0.380 [0.273; 0.533]

IDI

-

0.024 [0.020; 0.076]

-

0.006 [-0.005; 0.076]