Fig. 2

Association of 233 proteins with incident coronary heart disease in individuals (a) with type 2 diabetes (T2D), and (b) without T2D at baseline. Hazard ratios have been calculated per 1 SD increase in normalized protein expression values on a log2 scale. Effect estimates and p-values were derived from Cox regression analysis adjusted for age, sex, total cholesterol, high-density lipoprotein cholesterol, systolic blood pressure, antihypertensive medication use, and current smoking (Model 1). The red triangles represent the validated proteins in the validation study, identified using the false discovery rate (p_FDR < 0.05). The black dots represent significant proteins at the uncorrected level (p < 0.05) in the discovery study which were not replicated in the validation study. (c) Forest plot of validated proteins in KORA S4 and KORA-Age1 cohorts stratified by T2D status