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Table 1 Blood glucose and body weights for lean (db/ +), diabetic (db/db) and db/db plus OVZ/HS-1638 (HI) mice from 9–11week age

From: Heparanase inhibition as a systemic approach to protect the endothelial glycocalyx and prevent microvascular complications in diabetes

 

Age (week)

Db/ + (n = 5)

Db/db (n = 5)

Db/db + HI (n = 5)

Blood glucose

(mmol/L) ± SEM

9

8.0 ± 0.5

23.4 ± 1.6***

20.6 ± 0.8***

10

7.5 ± 0.4

25.9 ± 1.7***

25.2 ± 1.0***

11

7.9 ± 0.3

30.3 ± 0.9***

30.3 ± 0.8***

Body weight (g) ± SEM

9

27.7 ± 0.3

42.0 ± 1.0***

42.8 ± 0.03***

10

28.2 ± 0.5

44.1 ± 0.4***

45.1 ± 1.1***

11

29.0 ± 0.5

46.3 ± 0.3***

47.0 ± 1.4***

  1. SEM  standard error of the mean
  2. Two-way ANOVA with Bonferroni post-hoc tests indicated
  3. ***p < 0.001 compared to lean mice condition
  4. No significant differences were seen between db/db and db/db + HI
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Cardiovascular Diabetology

ISSN: 1475-2840