Fig. 4

Hazard ratios (HRs) for all-cause death and CV death by SII on a continuous scale in the whole cohort, and in the diabetic and nondiabetic cohorts. HRs with 95%CIs for all-cause death and CV death, accounting for SII on a continuous scale, are from Cox regression restricted cubic splines (RCS). Orange areas show the distribution of SII levels. The solid red line in each figure indicates the HR, and the dashed red lines indicate the 95%CI. Covariates in the multivariable RCS model included: age, sex, current smoker, comorbidities (hypertension, diabetes, dyslipidemia, CKD, heart failure, myocardial infarction), STEMI, Killip > I, primary PCI, peak TnT, CRP, serum creatinine, LVEF, as well as medications (aspirin, ACEI/ARB/ARNI, β-blocker). CKD chronic kidney disease, PCI percutaneous coronary intervention