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Table 1 Significant features at ANOVA presenting the 13 proteins potentially of interest as discriminant among groups. ANOVA was followed by post-hoc analysis with Fisher’s least significant difference method (Fisher’s LSD) in order to detect the paired significant comparisons. See also Fig. 2 for graphical display. UniProt Accession Number is the protein stable identifier according to https://www.uniprot.org/

From: Multiplexed MRM-based proteomics for identification of circulating proteins as biomarkers of cardiovascular damage progression associated with diabetes mellitus

Protein

UniProt Accession Number

ANOVA

F value

-log 10(p)

ANOVA

p

Fisher’s LSD

paired comparisons

Apolipoprotein A-IV

P06727

11.86

4.58

< 0.0001

DC-DN; DC-NC; DN-NC

Apolipoprotein C-III

P02656

11.70

4.53

< 0.0001

DC-DN; DC-NC

Afamin

P43652

11.25

4.37

< 0.0001

DN-DC; DC-NC; DN-NC

Vitamin K-dependent protein S

P07225

8.79

3.49

0.0003

DC-NC; DN-NC

Lysozyme C

P61626

8.06

3.23

0.0006

DC-DN; DC-NC

Kininogen-1

P01042

8.01

3.21

0.0006

DN-DC; DN-NC

Vitronectin

P04004

7.77

3.12

0.0008

DC-NC; DN-NC

Retinol-binding protein 4

P02753

7.50

3.02

0.001

DC-DN; DC-NC

Cystatin C

P01034

7.45

3.00

0.001

DC-DN; DC-NC

Alpha-2-macroglobulin

P01023

6.95

2.81

0.0016

DC-DN; DC-NC

Apolipoprotein C-II

P02655

5.44

2.23

0.0059

DC-DN; DC-NC

Complement factor B

P00751

5.30

2.18

0.0066

DC-NC

Mannan-binding lectin serine protease 2

P01034

5.22

2.15

0.0071

DC-NC; DN-NC