Protective role of arachidonic acid against diabetic myocardial ischemic injury: a translational study of pigs, rats, and humans

Table 1 Metabolites in coronary sinus blood differentially regulated between diabetic and non-diabetic pigs during MI

Rt (min)	m/z	Metabolite	LOG₂ fold change (A/C)	LOG₂ fold change (B/C)	LOG₂ fold change (A/B)	P value (t test) (A/B)
24.991	501	Arachidonic acid	− 3.13	− 2.33	− 5.103	0.036
13.876	349	Glutamine	− 2.52	− 1.24	− 2.909	0.033
12.799	56	L-Proline	− 2.36	− 1.11	− 1.262	0.001
10.676	359	Serine	− 0.3	− 0.57	− 0.704	0.014
11.983	243	1,4-Butanediamine (Putrescine)	0.52	0.25	0.254	0.022
17.038	147	Galactose	0.35	0.84	0.585	0.008
16.453	244	Ribitol	0.57	0.63	1.047	0.029
11.274	352	PGI2	− 2.81	− 1.38	− 1.423	0.032
27.383	502	Cholesterol	3.24	0.87	1.863	0.041
17.328	368	6-keto-PGF_1α	− 3.43	− 1.14	− 1.961	0.022
17.205	342	Glucose	3.12	1.26	3.787	0.026

Positive values in ‘LOG₂-fold change’ column represent the relatively increased metabolites. Negative values represent the relatively decreased metabolites
n = 10 in each group
Rt: retention time; m/z: mass-to-charge ratio
A: mean of DM + MI; B: mean of MI; C: mean of Sham group

ISSN: 1475-2840