The association between TyG and all-cause/non-cardiovascular mortality in general patients with type 2 diabetes mellitus is modified by age: results from the cohort study of NHANES 1999–2018

Yao, Younan; Wang, Bo; Geng, Tian; Chen, Jiyan; Chen, Wan; Li, Liwen

doi:10.1186/s12933-024-02120-6

Cardiovascular Diabetology

Table 4 Predictive power of various models with different IR indices (Reference = TyG model)

From: The association between TyG and all-cause/non-cardiovascular mortality in general patients with type 2 diabetes mellitus is modified by age: results from the cohort study of NHANES 1999–2018

Base model	+ TyG	+ HOMA-IR		+ QUICKI		+ HOMA-beta		+ Glucose		+ Triglyceride
	C-index (95% CI)	C-index (95% CI)	P value	C-index (95% CI)	P value	C-index (95% CI)	P value	C-index (95% CI)	P value	C-index (95% CI)	P value
All-cause mortality
Total	0.80 (0.78–0.82)	0.80 (0.78–0.82)	0.477	0.80 (0.78–0.81)	0.151	0.80 (0.78–0.81)	0.302	0.80 (0.78–0.82)	0.646	0.80 (0.78–0.82)	0.356
< 65 yrs	0.76 (0.73–0.79)	0.75 (0.72–0.79)	0.204	0.75 (0.71–0.78)	0.119	0.75 (0.71–0.78)	0.073	0.76 (0.73–0.79)	0.838	0.75 (0.72–0.79)	0.021
≥ 65 yrs	0.75 (0.73–0.77)	(0.75 (0.73–0.77)	0.909	0.75 (0.73–0.77)	0.726	0.75 (0.73–0.77)	0.658	0.75 (0.73–0.77)	0.972	0.75 (0.73–0.77)	0.775
Cardiovascular mortality
Total	0.82 (0.78–0.85)	0.82 (0.80–0.85)	0.982	0.82 (0.80–0.85)	0.911	0.82 (0.80–0.85)	0.882	0.82 (0.80–0.85)	0.816	0.82 (0.79–0.85)	0.404
< 65 yrs	0.82 (0.76–0.88)	0.82 (0.75–0.88)	0.788	0.82 (0.75–0.88)	0.736	0.81 (0.75–0.88)	0.626	0.82 (0.77–0.88)	0.496	0.81 (0.75–0.87)	0.579
≥ 65 yrs	0.77 (0.73–0.81)	0.78 (0.74–0.81)	0.298	0.78 (0.74–0.81)	0.319	0.78 (0.74–0.81)	0.472	0.77 (0.73–0.81)	0.938	0.77 (0.73–0.81)	0.802
Cancer mortality
Total	0.75 (0.71–0.79)	0.75 (0.71–0.79)	0.400	0.75 (0.71–0.79)	0.837	0.75 (0.71–0.79)	0.721	0.75 (0.71–0.79)	0.563	0.75 (0.71–0.79)	0.441
< 65 yrs	0.70 (0.62–0.78)	0.70 (0.62–0.78)	0.966	0.70 (0.62–0.77)	0.793	0.69 (0.62–0.77)	0.623	0.69 (0.62–0.77)	0.831	0.71 (0.63–0.79)	0.446
≥ 65 yrs	0.64 (0.58–0.70)	0.64 (0.58–0.71)	0.933	0.65 (0.59–0.71)	0.834	0.65 (0.58–0.71)	0.854	0.65 (0.58–0.71)	0.760	0.64 (0.58–0.70)	0.949
Non-cardiovascular mortality
Total	0.79 (0.77–0.81)	0.79 (0.77–0.81)	0.160	0.79 (0.77–0.81)	0.241	0.79 (0.77–0.81)	0.275	0.79 (0.77–0.81)	0.159	0.79 (0.77–0.81)	0.389
< 65 yrs	0.75 (0.72–0.79)	0.74 (0.70–0.78)	0.598	0.74 (0.70–0.78)	0.428	0.73 (0.69–0.77)	0.177	0.73 (0.69–0.78)	0.050	0.73 (0.70–0.77)	0.043
≥ 65 yrs	0.74 (0.72–0.77)	0.74 (0.72–0.77)	0.700	0.74 (0.72–0.77)	0.602	0.74 (0.72–0.77)	0.698	0.74 (0.72–0.77)	0.643	0.74 (0.72–0.77)	0.853

Base models included the covariates which were selected by the stepwise method in Model 3

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