Triglyceride-glucose index as a suitable non-insulin-based insulin resistance marker to predict cardiovascular events in patients undergoing complex coronary artery intervention: a large-scale cohort study

Table 3 C-statistics of the TyG index, TG/HDL-C ratio and METS-IR for predicting CV events and MACEs in patients undergoing complex PCI

	C-statistics	P value	NRI	P value	IDI	P value
CV events^a
Original model*	0.618 (0.586–0.650)	–	Reference	–	Reference	–
Original model + TyG index	0.627 (0.595–0.658)	< 0.001	0.12	0.031	0.14%	0.003
Original model + Ln(TG/HDL-C ratio)	0.624 (0.593–0.655)	0.061	0.02	0.746	0.06%	0.044
Original model + METS-IR	0.621 (0.589–0.652)	0.416	0.06	0.281	0.01%	0.514
MACEs^b
Original model	0.624 (0.589–0.660)	–	Reference	–	Reference	–
Original model + TyG index	0.634 (0.599–0.668)	0.001	0.14	0.021	0.13%	0.005
Original model + Ln(TG/HDL-C ratio)	0.628 (0.593–0.663)	0.161	0.02	0.799	0.04%	0.074
Original model + METS-IR	0.628 (0.593–0.663)	0.325	0.05	0.391	0.04%	0.426

CV cardiovascular, TyG triglyceride-glucose, TG triglyceride, HDL-C high-density lipoprotein cholesterol, METS-IR metabolic score for insulin resistance, BMI body mass index, CCS chronic coronary syndrome, ACS acute coronary syndrome, CAD coronary artery disease, MI myocardial infarction, PCI percutaneous coronary intervention, CABG coronary artery bypass grafting, PAD peripheral artery disease, CKD chronic kidney disease, SBP systolic blood pressure, DBP diastolic blood pressure, LVEF left ventricular ejection fraction, eGFR estimated glomerular filtration rate, HbA1c hemoglobin A1c, FPG fasting plasma glucose, TC total cholesterol, LDL-C low-density lipoprotein cholesterol, hsCRP high sensitivity C-reactive protein, SYNTAX synergy between PCI with taxus and cardiac surgery, CTO chronic total occlusion, ACEI angiotensin-converting enzyme inhibitor, ARB angiotensin II receptor blocker
^*Original model referred to the ACEF score, which was calculated by age (years)/left ventricular ejection fraction (%) + 1 (if serum creatinine value was > 2 mg/dL)
^aCV events were defined as a composite of CV death, nonfatal MI and nonfatal stroke
^bMACEs were defined as a composite of CV death and nonfatal MI

ISSN: 1475-2840