Fig. 1

ASGR1 deficiency promotes white adipose tissue hypertrophy on HFD. A Body weight over 20 weeks of HFD, in lower right the area under the curve (AUC) for body weight gain calculated over the 20 weeks of HFD of WT and ASGR1^−/− mice. B Visceral adipose tissue (VAT) weight after 20 weeks of HFD and (C) Representative pictures of VAT from WT and ASGR1^−/− mice. D Subcutaneous adipose tissue (SCAT) weight after 20 weeks of HFD in WT and ASGR1^−/− mice. E Representative 10 × images of VAT and SCAT sections stained with H&E in WT and ASGR1^−/− mice. F Adipocytes area quantification in VAT and G SCAT after 20 weeks of HFD in WT and ASGR1^−/− mice. H Food intake (grams/day) in WT and ASGR1^−/− mice on HFD. I Energy expenditure in WT and ASGR1^−/− mice on HFD measured in metabolic cages as (kcal/hours). J Brown adipose tissue (BAT) weight. K Locomotor activity L O₂ consumption and M CO₂ production measured using metabolic cages in WT and ASGR1^−/− mice on HFD. Data are obtained from three independent experimental groups. Each bar and error represent the mean ± SEM, *p < 0.05, **p < 0.01 and ***p < 0.001