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Table 2 Hormone levels during day 1 and day 2 clamps

From: The impact of prior exposure to hypoglycaemia on the inflammatory response to a subsequent hypoglycaemic episode

 

Antecedent normoglycaemia

Antecedent hypoglycaemia

Day 1

Day 2

Day 1

Day 2

Adrenaline (nmol/L)

Baseline

0.20 ± 0.12

0.23 ± 0.13

0.17 ± 0.10

0.14 ± 0.09#

Start hypo

0.18 ± 0.13

0.92 ± 1.08

0.76 ± 0.62

0.23 ± 0.12#

End of hypo

0.18 ± 0.14

2.68 ± 1.41*

1.84 ± 1.16*

1.45 ± 1.24* #

Noradrenaline (nmol/L)

Baseline

1.44 ± 0.72

1.79 ± 0.58

1.67 ± 0.62

1.61 ± 0.68

Start hypo

1.35 ± 0.63

2.06 ± 0.68

1.92 ± 0.62

1.67 ± 0.73

End of hypo

1.46 ± 0.75

2.51 ± 0.87*

1.99 ± 0.82*

2.36 ± 1.43*

Glucagon (ng/L)

Baseline

31.61 ± 10.49

30.86 ± 7.89

37.16 ± 25.13

35.99 ± 26.87

Start hypo

 

31.44 ± 12.69

 

33.77 ± 10.13

End of hypo

25.07 ± 5.99*

46.29 ± 19.69*

62.82 ± 54.15*

48.28 ± 23.49

Cortisol (umol/L)

Baseline

0.42 ± 0.10

0.38 ± 0.10

0.43 ± 0.13

0.37 ± 0.12

Start hypo

 

0.25 ± 0.06

 

0.23 ± 0.11

End of hypo

0.28 ± 0.08

0.53 ± 0.11*

0.51 ± 0.14*

0.48 ± 0.15*

Growth hormone (mE/L)

Baseline

12.01 ± 13.47

8.37 ± 8.49

9.50 ± 11.08

5.45 ± 7.26

Start hypo

 

4.96 ± 9.81

 

3.63 ± 5.27

End of hypo

7.06 ± 7.89

49.23 ± 28.19*

35.75 ± 18.65*

28.34 ± 14.09*#

  1. *p < 0.05 versus baseline
  2. #p < 0.05 versus antecedent normoglycaemia Day 2
  3. p < 0.05 versus Day 1