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Table 2 HR and 95%CIs of hs-cTnT and hs-cTnI (Abbott) concentrations regarding all-cause and cardiac-specific mortality

From: Distribution and prognostic value of high-sensitivity cardiac troponin T and I across glycemic status: a population-based study

 

Normoglycemia

Prediabetes

Diabetes

HR (95% CI)a

P-value

HR (95% CI)a

P-value

HR (95% CI)a

P-value

All-cause mortality

 Univariable

  hs-cTnT

3.03 (2.67–3.44)

 < 0.001

2.91 (2.48–3.41)

 < 0.001

1.97 (1.75–2.21)

 < 0.001

  hs-cTnI (Abbott)

3.09 (2.63–3.63)

 < 0.001

3.15 (2.74–3.61)

 < 0.001

2.23 (1.99–2.52)

 < 0.001

  hs-cTnI (Siemens)

2.75 (2.18–3.46)

 < 0.001

3.73 (2.87–4.85)

 < 0.001

2.33 (1.82–2.99)

 < 0.001

  hs-cTnI (Ortho)

3.79 (3.03–4.73)

 < 0.001

4.18 (3.17–5.50)

 < 0.001

2.79 (2.30–3.40)

 < 0.001

Multivariableb

 hs-cTnT

1.31 (1.12–1.53)

 < 0.001

1.46 (1.22–1.75)

 < 0.001

1.56 (1.42–1.71)

 < 0.001

 hs-cTnI (Abbott)

1.36 (1.15–1.62)

 < 0.001

1.65 (1.43–1.91)

 < 0.001

1.35 (1.17–1.55)

 < 0.001

 hs-cTnI (Siemens)

1.06 (0.9–1.25)

0.48

1.55 (1.19–2.02)

0.001

1.21 (0.95–1.56)

0.13

 hs-cTnI (Ortho)

1.31 (1.11–1.56)

0.002

1.36 (1.11–1.66)

0.003

1.24 (1.04–1.49)

0.02

Cardiac-specific mortality

 Univariable

  hs-cTnT

3.53 (3.05–4.08)

 < 0.001

3.65 (2.75–4.84)

 < 0.001

2.13 (1.80–2.51)

 < 0.001

  hs-cTnI (Abbott)

3.84 (3.07–4.82)

 < 0.001

4.20 (3.46–5.10)

 < 0.001

2.75 (2.21–3.41)

 < 0.001

  hs-cTnI (Siemens)

4.83 (3.08–7.56)

 < 0.001

6.86 (5.06–9.3)

 < 0.001

3.24 (1.95–5.38)

 < 0.001

  hs-cTnI (Ortho)

6.94 (4.65–10.4)

 < 0.001

9.28 (5.81–14.8)

 < 0.001

5.51 (3.70–8.21)

 < 0.001

Multivariableb

 hs-cTnT

1.52 (1.23–1.86)

 < 0.001

1.97 (1.37–2.83)

 < 0.001

1.77 (1.48–2.12)

 < 0.001

 hs-cTnI (Abbott)

1.74 (1.34–2.26)

 < 0.001

2.53 (1.87–3.44)

 < 0.001

1.83 (1.33–2.53)

 < 0.001

 hs-cTnI (Siemens)

1.5 (0.91–2.47)

0.11

3.57 (2.15–5.95)

 < 0.001

1.68 (0.84–3.34)

0.14

 hs-cTnI (Ortho)

2.36 (1.41–3.95)

0.001

2.80 (1.34–5.83)

0.006

2.85 (1.76–4.62)

 < 0.001

  1. aPer 1-standard deviation increase of natural log-transformed hs-cTn concentrations
  2. bHs-cTn were adjusted in model 2 which incorporated age, sex, race-ethnicity, smoking status, systolic blood pressure, taking prescribed medication for hypertension, total cholesterol, and high-density lipoprotein cholesterol, estimated glomerular filtration rate, and N-terminal pro-brain natriuretic peptide
  3. HR hazard ratio, CI confidence interval, hs-cTn high-sensitivity cardiac troponin
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Cardiovascular Diabetology

ISSN: 1475-2840