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Table 1 Baseline characteristic of participants according to the tertiles of PA PRS

From: Primary aldosteronism and lower-extremity arterial disease: a two-sample Mendelian randomization study

 

Individuals with diabetes

Individuals without diabetes

0.80–10.10

10.10–13.88

13.88–23.13

0–10.03

10.03–13.82

13.82–23.14

Number

13105

13503

13105

138373

142566

138,373

Age (years)

59.77 (7.09)

59.51 (7.14)

59.70 (7.11)

56.50 (8.04)

56.48 (8.06)

56.49 (8.05)

Female, number (%)

7783 (59.4)

8085 (59.9)

7883 (60.2)

61337 (44.3)

63420 (44.5)

61,339 (44.3)

Smoking, number (%)

1615 (12.3)

1774 (13.1)

1694 (12.9)

14130 (10.2)

14541 (10.2)

14,121 (10.2)

Body Mass Index (kg/m2)

31.44 (5.73)

31.45 (5.79)

31.42 (5.77)

27.00 (4.46)

27.00 (4.48)

27.04 (4.50)

Total Cholesterol (mmol/L)

4.98 (1.25)

4.99 (1.25)

4.97 (1.24)

5.79 (1.11)

5.78 (1.11)

5.78 (1.11)

Triglycerides (mmol/L)

2.27 (1.31)

2.26 (1.28)

2.25 (1.26)

1.71 (0.99)

1.70 (0.98)

1.70 (0.98)

HDL-C (mmol/L)

1.22 (0.33)

1.22 (0.33)

1.23 (0.33)

1.48 (0.38)

1.47 (0.38)

1.47 (0.38)

LDL-C (mmol/L)

3.06 (0.94)

3.07 (0.93)

3.06 (0.93)

3.62 (0.85)

3.61 (0.85)

3.61 (0.85)

HbAlc (%)

6.52 (1.20)

6.54 (1.23)

6.52 (1.20)

5.34 (0.35)

5.34 (0.35)

5.34 (0.37)

SBP (mmHg)

144.53 (18.98)

144.58 (19.35)

145.02 (19.13)

139.21 (19.50)

139.43 (19.67)

139.68 (19.76)

DBP (mmHg)

82.75 (10.82)

83.10 (10.86)

82.95 (10.80)

82.00 (10.66)

82.11 (10.63)

82.18 (10.68)

LEAD, number (%)

201 (1.5)

235 (1.7)

248 (1.9)

336 (0.2)

403 (0.3)

348 (0.3)

Gangrene, number (%)

23 (0.2)

44 (0.3)

48 (0.4)

20 (0.01)

14 (0.01)

15 (0.01)

Amputation, number (%)

31 (0.2)

36 (0.3)

53 (0.4)

38 (0.02)

26 (0.02)

25 (0.02)

  1. Tertile tertiles of PA PRS, PA primary aldosteronism, PRS polygenic risk scores, HDL-C high density lipoprotein cholesterol, LDL-C low density lipoprotein cholesterol, HbAlc glycated haemoglobin, SBP Systolic Blood Pressure, DBP Diastolic Blood Pressure, LEAD Lower Extremity Arterial Disease