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Table 3 Risk of AVC progression across LDL-C vs RC concordant/discordant groups by LDL-C median and RC median

From: Remnant cholesterol and the risk of aortic valve calcium progression: insights from the MESA study

LDL-C groups

RC groups

Events/No. at risk

Model 1 HR (95% CI)

P value

Model 2 HR (95% CI)

P value

Model 3 HR (95% CI)

P value

LDL-C, mg/dL

  < 117.6

–

290/2794

Reference

1.0

Reference

1.0

Reference

1.0

  ≥ 117.6

–

278/2803

0.972 (0.824–1.147)

0.736

1.060 (0.894–1.257)

0.500

1.057 (0.891–1.254)

0.525

RC, mg/dL

 –

 < 21.6

245/2786

Reference

1.0

Reference

1.0

Reference

1.0

 –

 ≥ 21.6

323/2811

1.389 (1.171–1.647)

 < 0.001

1.284 (1.077–1.531)

0.005

1.280 (1.073–1.527)

0.006

Cut points: LDL-C, 117.6 mg/dL; RC, 21.6 mg/dL

  < Cut point

 < Cut point

150/1743

Reference

1.0

Reference

1.0

Reference

1.0

 ≥ Cut point

140/1051

1.718 (1.359–2.171)

 < 0.001

1.529 (1.203–1.945)

0.001

1.528 (1.201–1.943)

0.001

  ≥ Cut point

 < Cut point

95/1043

1.108 (0.856–1.434)

0.434

1.230 (0.948–1.598)

0.119

1.231 (0.948–1.598)

0.119

 ≥ Cut point

183/1760

1.287 (1.034–1.603)

0.024

1.295 (1.034–1.621)

0.024

1.289 (1.029–1.616)

0.027

  1. Model 1: Adjusted for age, race and sex. Model 2: Adjusted for Model 1 covariates plus antihypertensive medication use, BMI, drinking status, FG, hypoglycemic medication use, lipid-lowering medication use, SBP and smoking status. Model 3: Adjusted for Model 2 covariates plus CRP and eGFR
  2. AVC aortic valve calcium, BMI body mass index, CI confidence interval, CRP C-reactive protein, eGFR estimate glomerular filtration rate, FG fasting glucose, HDL-C high-density lipoprotein cholesterol, HR hazard ratio, LDL-C low-density lipoprotein cholesterol, RC remnant cholesterol, SBP systolic blood pressure
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Cardiovascular Diabetology

ISSN: 1475-2840