Table 1 Characteristics of the used genome-wide association study in the study
Phenotypes | Study/consortium | Cases/ controls | Adjusted variables | PubMed ID |
|---|---|---|---|---|
Mitochondrial DNA copy number | UK Biobank | 395,718 | Age, age2, sex, chip type, 20 genetic principal components, and blood cell counts (white blood cell, platelet, and neutrophil counts) | 35023831 |
Mitochondrial DNA copy number in the replication analysis | CHARGE and UK Biobank | 465,809 | Age, sex, principal components, DNA collection site, family structure and cell composition | 34859289 |
Obesity | FinnGen consortium | 18,330/324,070 | Age, sex, genotyping batch, 10 principal components | – |
Hypertension | FinnGen consortium | 98,683/243,756 | Age, sex, genotyping batch, 10 principal components | – |
Dyslipidemia | FinnGen consortium | 22,460/296,380 | Age, sex, genotyping batch, 10 principal components | – |
T2DM | DIAGRAM | 74,124/824,006 | BMI | 30297,969 |
CAD | CARDIOGRAMPLUSC4D | 60,801/123,504 | Sex, age, and generation (Original or Offspring Cohort) | 26343387 |
Stroke | MEGASTROKE | 40,585/406,111 | Age, sex | 29531354 |
Ischemic stroke | MEGASTROKE | 34,217/406,111 | Age, sex | 29531354 |
Heart failure | HERMES | 47,309/930,014 | Age, sex, and principal components | 31919418 |