Fig. 6

 Correlations of circulating MMP12 with clinical and laboratory indicators for cardiometabolic diseases (A) Violin plots of MMP12 concentrations in serum from healthy volunteers (HV) and from patients with metabolic syndrome (MS). Groups were compared using the Mann-Whitney U test (n = 65 − 63). (B) Receiver operating characteristic (ROC) curve for the prediction of MS using MMP12. The graph shows the ROC curve, area under the curve (AUC), 95% confidence interval, and the best cut-off value according to Youden index along with specificity and sensitivity. (C) Heat map for correlation analyses of serum MMP12 concentrations with body mass index (BMI), as well as serum levels of glucose, lipoprotein (a) (Lp(a)), interleukin 6 (IL-6), and bilirubin levels. Correlations were quantified using Spearman’s correlation coefficient (r). Correlation plots of circulating MMP12 concentrations (pg/ml) with (D) BMI (kg/m²), (E) glucose (mg/dl), (F) Lp(a) (mg/dl), (G) IL-6 (mg/dl), and (H) bilirubin (mg/dl) (n = 128)