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Fig. 5 | Cardiovascular Diabetology

Fig. 5

From: Genetic deletion of MMP12 ameliorates cardiometabolic disease by improving insulin sensitivity, systemic inflammation, and atherosclerotic features in mice

Fig. 5

Reduced atherosclerotic plaque size and collagen content in aortas of DKO mice. Female LdlrKO and DKO mice were fed a HFSC diet for 20 weeks. (A) Oil red O staining of en face aortas and quantification of atherosclerotic lesions in the (B) total aorta and (C) aortic arch. (D) Oil red O staining of aortic valve sections (magnification, 5X) and (E) plaque area quantification. (F) Masson´s Trichrome staining of aortic valve sections (magnification, 5X) and quantification of (G) collagen-positive area and (H) necrotic core. Data represent mean values (n = 8–11) ± SD. *p < 0.05; ** p ≤ 0.01

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Cardiovascular Diabetology

ISSN: 1475-2840