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Fig. 1 | Cardiovascular Diabetology

Fig. 1

From: Genetic deletion of MMP12 ameliorates cardiometabolic disease by improving insulin sensitivity, systemic inflammation, and atherosclerotic features in mice

Fig. 1

Reduced circulating lipid concentrations and improved glucose tolerance and insulin sensitivity in DKO mice. Male LdlrKO and DKO mice were fed HFSC for 16 weeks. (A) Body weight curves (n = 6–7) and (B) tissue weights relative to total body weight (n = 7). (C) Plasma triglyceride (TG), total cholesterol (TC), free cholesterol (FC), and cholesteryl ester (CE) concentrations in 12-h fasted mice (n = 7–9). Lipoprotein profiles of (D) TG and (E) TC in pooled plasma samples (n = 7–9) after fast protein liquid chromatography separation. (F) Plasma glucose concentrations in 12-h fasted mice (n = 6–7) and during (G) oral glucose tolerance (n = 4–6) and (I) insulin tolerance tests (n = 7). Area under the curve (A.U.C) calculated from (H) oral glucose tolerance and (J) insulin tolerance tests. All data represent mean values ± SD. *p < 0.05, **p ≤ 0.01

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Cardiovascular Diabetology

ISSN: 1475-2840