An elevated triglyceride-glucose index predicts adverse outcomes and interacts with the treatment strategy in patients with three-vessel disease

Zhang, Yu; Zhang, Ce; Jiang, Lin; Xu, Lianjun; Tian, Jian; Zhao, Xueyan; Wang, Dong; Zhang, Yin; Sun, Kai; Zhang, Channa; Xu, Bo; Zhao, Wei; Hui, Rutai; Gao, Runlin; Wang, Jizheng; Feng, Xinxing; Yuan, Jinqing; Song, Lei

doi:10.1186/s12933-023-02063-4

Cardiovascular Diabetology

Table 2 Risk of MACE across disease phenotypes, TyG index groups, and treatment strategies

From: An elevated triglyceride-glucose index predicts adverse outcomes and interacts with the treatment strategy in patients with three-vessel disease

	CABG vs. MT		PCI vs. MT		CABG vs. PCI
	Adjusted HR (95% CI)	Adjusted P-value	Adjusted HR (95% CI)	Adjusted P-value	Adjusted HR (95% CI)	Adjusted P-value
Grouped by clinical presentations and diabetes*
Patients with SAP and a normal TyG index, without diabetes	0.443 (0.344–0.570)	< 0.001	0.827 (0.661–1.035)	0.097	0.536 (0.417–0.689)	< 0.001
Patients with SAP and an elevated TyG index, without diabetes	0.776 (0.315–1.910)	0.581	1.136 (0.442–2.921)	0.791	0.683 (0.272–1.714)	0.416
Patients with SAP, diabetes and a normal TyG index	0.568 (0.401–0.804)	0.001	1.049 (0.773–1.425)	0.759	0.541 (0.386–0.759)	< 0.001
Patients with SAP, diabetes and an elevated TyG index	0.541 (0.288–1.018)	0.057	0.874 (0.500–1.527)	0.635	0.620 (0.335–1.146)	0.127
Patients with ACS and a normal TyG index, without diabetes	0.510 (0.417–0.624)	< 0.001	0.790 (0.668–0.933)	0.006	0.646 (0.528–0.790)	< 0.001
Patients with ACS and an elevated TyG index, without diabetes	0.467 (0.219–0.997)	0.049	0.720 (0.375–1.383)	0.324	0.649 (0.303–1.390)	0.265
Patients with ACS, diabetes and a normal TyG index	0.391 (0.290–0.528)	< 0.001	0.758 (0.598–0.960)	0.022	0.516 (0.379–0.703)	< 0.001
Patients with ACS, diabetes and an elevated TyG index	0.309 (0.179–0.533)	< 0.001	0.743 (0.519–1.065)	0.106	0.416 (0.239–0.722)	0.002
Grouped by left main involvement^#
Patients with left main involvement and a normal TyG index	0.529 (0.427–0.656)	< 0.001	0.739 (0.572–0.956)	0.021	0.716 (0.551–0.930)	0.012
Patients with left main involvement and an elevated TyG index	0.457 (0.255–0.821)	0.009	0.653 (0.343–1.244)	0.195	0.700 (0.345–1.421)	0.324

*Adjusted for age, sex, body mass index, family history of coronary artery disease, previous myocardial infarction, previous stroke, hypertension, hyperlipidaemia, chronic obstructive pulmonary disease, peripheral artery disease, chronic kidney disease, current/former smoker, left ventricular ejection fraction, creatinine clearance, left main involvement and SYNTAX score. ^#Adjusted for age, sex, body mass index, family history of coronary artery disease, previous myocardial infarction, previous stroke, hypertension, diabetes, hyperlipidaemia, chronic obstructive pulmonary disease, peripheral artery disease, chronic kidney disease, current/former smoker, acute coronary syndrome, left ventricular ejection fraction, creatinine clearance, and SYNTAX score
ACS, acute coronary syndrome; CABG, coronary artery bypass grafting; CI, confidence interval; HR, hazard ratio; MACE, major adverse cardiac events; MT, medical therapy; PCI, percutaneous coronary intervention; SAP, stable angina pectoris; TyG index, triglyceride-glucose Index

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