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Table 1 Baseline characteristics of the study population according to the TyG index tertiles

From: Prognostic value of triglyceride-glucose index in patients with chronic coronary syndrome undergoing percutaneous coronary intervention

Variables

Total (n = 1353)

T1 (n = 438)

T2 (n = 458)

T3 (n = 457)

P value

TyG index

8.83 (8.47, 9.18)

8.3 (8.07, 8.46)

8.82 (8.72, 8.93)

9.32 (9.17, 9.58)

< 0.001

MACEs (n, %)

542 (40.06)

129 (29.45)

148 (32.31)

265 (57.99)

< 0.001

Demographics

     

Male (n, %)

979 (72.36)

328 (74.89)

325 (70.96)

326 (71.33)

0.352

Age (years)

64 (57, 71)

63 (56, 71)

64 (57, 70)

67 (58, 74)

< 0.001

BMI (kg/m2)

24.97 (23.29, 27.18)

24.37 (22.56, 26.42)

24.79 (23.24, 27.43)

25.61 (23.88, 27.66)

< 0.001

SBP (mmHg)

134 (123, 143)

134 (121, 143)

134 (122, 140)

134 (127, 146)

0.008

DBP (mmHg)

78 (71, 84)

78 (70, 84)

78 (71, 82)

78 (73, 85)

0.194

HR (bpm)

74 (68, 79)

73 (66, 78)

74 (68, 76)

74 (70, 80)

< 0.001

Case history (n, (%)

     

Smoking

599 (44.27)

180 (41.1)

201 (43.89)

218 (47.7)

0.135

Drinking

300 (22.17)

94 (21.46)

95 (20.74)

111 (24.29)

0.395

Diabetes

612 (45.23)

144 (32.88)

207 (45.2)

261 (57.11)

< 0.001

Hypertension

1026 (75.83)

305 (69.63)

361 (78.82)

360 (78.77)

0.001

Stroke

233 (17.22)

76 (17.35)

59 (12.88)

98 (21.44)

0.003

OMI

238 (17.59)

77 (17.58)

77 (16.81)

84 (18.38)

0.824

Dyslipidemia

889 (65.71)

280 (63.93)

281 (61.35)

328 (71.77)

0.003

Familial CVDs

366 (27.05)

101 (23.06)

122 (26.64)

143 (31.29)

0.021

Coronary lesions (n, %)

     

One-vessel disease

963 (71.18)

319 (72.83)

329 (71.83)

315 (68.93)

0.405

Two-vessel disease

299 (22.1)

92 (21)

100 (21.83)

107 (23.41)

0.676

Multi-vessel disease

91 (6.73)

27 (6.16)

29 (6.33)

35 (7.66)

0.617

Number of stents (n, %)

     

One-DES implantation

625 (46.19)

211 (48.17)

221 (48.25)

193 (42.23)

0.113

Two-DES implantation

426 (31.49)

127 (29)

161 (35.15)

138 (30.2)

0.107

Multi-DES implantation

302 (22.32)

100 (22.83)

76 (16.59)

126 (27.57)

< 0.001

Cardiovascular medications (n, %)

     

Aspirin

1337 (98.82)

435 (99.32)

456 (99.56)

446 (97.59)

0.011

Clopidogrel/Ticagrelor

1348 (99.63)

438 (100)

456 (99.56)

454 (99.34)

0.259

Statins

1305 (96.45)

429 (97.95)

441 (96.29)

435 (95.19)

0.081

ACEI/ARB

671 (49.59)

210 (47.95)

238 (51.97)

223 (48.8)

0.444

β-blockers

950 (70.21)

302 (68.95)

324 (70.74)

324 (70.9)

0.780

CCB

440 (32.52)

128 (29.22)

147 (32.1)

165 (36.11)

0.087

Nitrates

361 (26.68)

121 (27.63)

140 (30.57)

100 (21.88)

0.010

Diuretics

278 (20.55)

93 (21.23)

84 (18.34)

101 (22.1)

0.338

Laboratory measurements

     

Neu (109/L)

4.36 (3.4, 4.99)

4.12 (3.08, 4.74)

4.36 (3.54, 4.87)

4.36 (3.64, 5.23)

< 0.001

Lym (109/L)

1.81 (1.43, 2.08)

1.71 (1.36, 2)

1.81 (1.46, 2.08)

1.81 (1.49, 2.18)

< 0.001

PLT (109/L)

209 (174, 238)

207 (164, 232)

209 (179, 231)

209 (179, 248)

0.005

Hb (g/L)

134 (126, 144)

134 (124, 143)

134 (128, 145)

134 (126, 146)

0.099

ALT (U/L)

21 (14, 30)

19 (14, 26)

22 (15, 30)

23 (15, 35)

< 0.001

AST (U/L)

19 (16, 25)

19 (16, 24)

19 (16, 25)

19 (15, 26)

0.647

TC (mmol/L)

3.83 (3.21, 4.71)

3.51 (2.89, 4.08)

3.77 (3.2, 4.67)

4.42 (3.58, 5.25)

< 0.001

TG (mmol/L)

1.4 (1.04, 1.9)

0.89 (0.76, 1.06)

1.43 (1.22, 1.64)

2.13 (1.8, 2.69)

< 0.001

LDL-C (mmol/L)

2.29 (1.86, 2.88)

2.09 (1.62, 2.5)

2.27 (1.87, 2.9)

2.63 (2.08, 3.24)

< 0.001

HDL-C (mmol/L)

1.01 (0.86, 1.17)

1.05 (0.89, 1.25)

1 (0.87, 1.14)

0.97 (0.82, 1.13)

< 0.001

Lp (a) (mg/L)

159.75 (55.76, 227.47)

150.65 (52.9, 232.88)

171.42 (55.76, 246.13)

168.67 (58.83, 219.74)

0.768

HCY (µmol/L)

13.65 (11.34, 17.31)

13.39 (11.06, 16.54)

13.37 (11.06, 17.27)

14.18 (11.76, 18.48)

0.002

Hs-CRP (mg/L)

2.17 (0.93, 4.81)

1.71 (0.8, 4.81)

1.99 (0.84, 4.81)

2.74 (1.25, 4.81)

< 0.001

Scr (µmol/L)

74 (62.7, 84.7)

74.1 (64.3, 83.9)

74 (62.9, 84.8)

73.9 (61.5, 87.1)

0.946

FBG (mmol/L)

6.11 (5.22, 6.54)

5.32 (4.85, 6.21)

6.11 (5.31, 6.29)

6.43 (6, 7.74)

< 0.001

HbA1c (%)

6.1 (5.7, 7.1)

5.9 (5.6, 6.4)

6.2 (5.8, 6.9)

6.6 (5.8, 7.9)

< 0.001

PAD indicators

     

baPWV (m/s)

17.04 (15.32, 21.68)

16.21 (15.21, 20.82)

16.8 (15.12, 21.12)

19.28 (15.66, 22.66)

< 0.001

ABI

1.09 (0.96, 1.18)

1.12 (0.98, 1.18)

1.11 (0.99, 1.18)

1.03 (0.9, 1.16)

< 0.001

FMD (%)

7 (6.1, 8.4)

7.1 (6.3, 8.5)

7.2 (6.2, 8.5)

6.6 (6, 8.2)

< 0.001

Echocardiography

     

LAD (mm)

37 (35, 40)

36 (34, 39.25)

37.69 (36, 39)

38 (35, 40)

< 0.001

LVEF (%)

65 (60, 70)

66 (61, 70)

66 (60, 70)

65 (59, 70)

0.163

LVDd (mm)

50 (47, 53)

50 (47, 53)

50 (47, 53)

51 (47, 54)

0.031

IVST (mm)

10 (9, 11)

10 (9, 11)

10 (9, 11)

10 (10, 11)

< 0.001

PWT (mm)

9 (8, 10)

9 (8, 9.6)

9 (8, 10)

9 (8, 10)

< 0.001

  1. TyG, triglyceride-glucose; T1, tertile 1; T2, tertile 2; T3, tertile 3; MACE, major adverse cardiovascular event; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; HR, heart rate; OMI, old myocardial infarction; CVD, cardiovascular disease; DES, drug-eluting stent; ACEI, angiotensin converting enzyme inhibitor; ARB, angiotensin receptor blocker; CCB, calcium channel blockers; Neu, neutrophil; Lym, lymphocyte; PLT, platelets; Hb, hemoglobin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; TC, total cholesterol; TG, triglyceride; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; Lp (a), lipoprotein (a); HCY, homocysteine; Hs-CRP, hypersensitive C-reactive protein; Scr, serum creatinine; FBG, fasting blood glucose; HbA1c, glycosylated hemoglobin; PAD, peripheral artery disease; baPWV, brachial-ankle pulse wave velocity; ABI, ankle-brachial index; FMD, brachial artery flow-mediated vasodilatation; LAD, left atrial diameter; LVEF, left ventricular ejection fraction; LVDd, left ventricular end-diastolic diameter; IVST, interventricular septal thickness; PWT, left ventricular posterior wall thickness
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Cardiovascular Diabetology

ISSN: 1475-2840