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Table 2 Association between co-exposure to CumTyG and CumBP and CVD incidence

From: Temporal relationship between triglyceride-glucose index and blood pressure and their joint cumulative effect on cardiovascular disease risk: a longitudinal cohort study

 

Combination of CumBP and CumTyG, HRs (95% CIs)

CumSBP < 130 mmHg

CumTyG < 8.61

CumSBP < 130 mmHg

CumTyG ≥ 8.61

130 ≤ CumSBP < 140 mmHg

CumTyG < 8.61

130 ≤ CumSBP < 140 mmHg

CumTyG ≥ 8.61

CumSBP ≥ 140 mmHg

CumTyG < 8.61

CumSBP ≥ 140 mmHg

CumTyG ≥ 8.61

Event/total

522/18,098

606/13,309

358/4632

592/6239

700/5426

1203/8609

Incidence rate

2.96

4.71

8.30

10.19

14.69

15.85

Unadjusted model

Reference

1.58 (1.40, 1.78)

2.86 (2.50, 3.27)

3.47 (3.09, 3.91)

5.20 (4.64, 5.82)

5.58 (5.03, 6.18)

Model 1

Reference

1.52 (1.35, 1.71)

2.03 (1.78, 2.33)

2.77 (2.46, 3.12)

3.00 (2.67, 3.38)

3.75 (3.37, 4.16)

Model 2

Reference

1.39 (1.24, 1.57)

1.94 (1.69, 2.22)

2.40 (2.12, 2.71)

2.74 (2.43, 3.10)

3.07 (2.74, 3.45)

Model 3

Reference

1.40 (1.24, 1.57)

1.92 (1.68, 2.20)

2.38 (2.11, 2.69)

2.73 (2.41, 3.08)

3.04 (2.71, 3.42)

 

CumDBP < 80 mmHg

CumTyG < 8.61

CumDBP < 80 mmHg

CumTyG ≥ 8.61

80 ≤ CumDBP < 90 mmHg

CumTyG < 8.61

80 ≤ CumDBP < 90 mmHg

CumTyG ≥ 8.61

CumDBP ≥ 90 mmHg

CumTyG < 8.61

CumDBP ≥ 90 mmHg

CumTyG ≥ 8.61

Event/Total

367/12,743

362/7331

676/10,600

1021/12,596

537/4813

1018/8230

Incidence rate

2.98

5.21

6.75

8.61

12.28

13.61

Unadjusted model

Reference

1.75 (1.51, 2.02)

2.27 (2.00, 2.57)

2.89 (2.56, 3.25)

4.16 (3.65, 4.76)

4.60 (4.08, 5.19)

Model 1

Reference

1.59 (1.37, 1.84)

1.74 (1.53, 1.97)

2.43 (2.16, 2.74)

2.88 (2.52, 3.30)

3.65 (3.24, 4.12)

Model 2

Reference

1.43 (1.23, 1.65)

1.65 (1.45, 1.87)

2.08 (1.83, 2.35)

2.55 (2.22, 2.93)

2.88 (2.53, 3.28)

Model 3

Reference

1.42 (1.23, 1.64)

1.64 (1.44, 1.86)

2.07 (1.83, 2.34)

2.51 (2.19, 2.88)

2.85 (2.50, 3.24)

  1. Model 1: adjusted for age (continuous), gender(categorical)
  2. Model 2: model 1 + heart rate, BMI (continuous), hs-CRP (continuous), HDL (continuous), antihypertensives (yes or no), lipid-lowering drugs (yes or no)
  3. Model 3: model 2 + smoking status, drinking status, physical exercise
  4. The incident rate is per 1000 person-years
  5. P for interaction: CumTyG × CumSBP = 0.0149; P for interaction: CumTyG× CumDBP = 0.0441