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Table 5 Overview of the model inputs for costs incurred by patients and caregivers

From: Cost-effectiveness of finerenone in chronic kidney disease associated with type 2 diabetes in The Netherlands

Parameter

Value

References

Hourly wage patient

€35

CBS statline [41]

Opportunity costs informal care

€18

Dutch costing manual [35]

Average labour participation wage (CKD 1/2)

69%

CBS [42]

Average labour participation wage (CKD 3 to5)

68%

Alma et. al[40]

Average labour participation wage (Dialysis)

52%

Alma et. al. [40]

Average labour participation wage (Transplantation)

64%

Alma et. al. [40]

Average working hours per week (Dialysis)

24 h per week

Alma et. al. [40]

Average working hours per week (Transplantation)

28 h per week

Alma et. al. [40]

Age at retirement

67 years

CBS [42]

Friction days

85 days

Dutch costing manual [35]

Costs for patients and caregivers—resource use

 CKD 3a/b

Short term productivity loss: 1.8 h per day

Alma et. al. [40]

Expert opinion

Informal care: 0 days

 CKD 4

Short term productivity loss: 1.8 h per day

Alma et. al. [40]

Expert opinion

Informal care: 4 days

 CKD 5 (without RRT)

Short term productivity loss: 1.8 h per day

Alma et. al. [40]

Expert opinion

Informal care: 5 days

 Acute dialysis

Percentage of patients on sick leave: 23% Short term productivity loss: 3.2 h per day

Alma et. al. [40]

De Vries et. al. [39]

and confirmed by expert opinion

Informal care: 15 days

 Post-acute dialysis

Short term productivity loss: 3.2 h per day

Alma et. al. [40]

De Vries et al. [39]

and confirmed by expert opinion

Informal care: 15 days

 Acute kidney transplantation

Percentage of patients on sick leave: 58% Short term productivity loss: 2 h per day

Alma et. al. [40]

De Vries et. al. [39]

and confirmed by expert opinion

Informal care: 15 days

 Post-acute kidney transplantation

Short term productivity loss: 2 h per day

Alma et. al. [40]

De Vries et. al. [39]

Informal care: 0 days

 Acute MI

Productivity losses: 20 days per cycle

Kotseva et. al. [38]

Assumption validated with expert

Informal care: 4 days

 Acute stroke

Productivity losses: 19 days per cycle

Kotseva et. al. [38]

Assumption validated with expert

Informal care: 4 days

 Acute hospitalization for heart failure

Productivity losses: 20 days per cycle

Kotseva et. al. [38]

Assumption validated with expert

Informal care: 4 days

 Post-acute MI

Productivity losses: 0.7 days per cycle

Kotseva et. al. [38]

Assumption validated with expert

Informal care: 0.02 days per cycle

 Post-acute stroke

Productivity losses: 3 days per cycle

Kotseva et. al. [38]

Assumption validated with expert

Informal care: 0.7 days

 Post-acute hospitalization for heart failure

Productivity losses: 3 days per cycle

Kotseva et. al. [38]

Assumption validated with expert

Informal care: 0.6 days

  1. CBS Central Agency for Statistics, CKD chronic kidney disease, CV cardiovascular, DDD daily defined dose, Egfr estimated glomerular filtration rate, IS ischaemic stroke, MI myocardial infarction;