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Fig. 2 | Cardiovascular Diabetology

Fig. 2

From: SIRT1 mediates the inhibitory effect of Dapagliflozin on EndMT by inhibiting the acetylation of endothelium Notch1

Fig. 2

DAPA ameliorates ISO-induced myocardial perivascular fibrosis and cardiac dysfunction by impairing EndMT. A Results for the GSEA enrichment of DEGs. B Enrichment analysis of biological processes involved in the regulation of EMT or EndMT-related pathways. C Enrichment analysis of KEGG signaling pathways involved in regulating EMT or EndMT-related pathways. D Enrichment of EMT or EndMT marker genes. E The Western blotting analysis of EndMT-related proteins and quantitative analysis (n = 3). F The Western blotting analysis of SIRT1 and quantitative analysis (n = 3). *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001 vs. Vehicle group; #p < 0.05, ##p < 0.01, ###p < 0.001 and ####p < 0.0001 vs. the ISO group

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Cardiovascular Diabetology

ISSN: 1475-2840