| Model 1 |  |  |  | Model 2 |  |  |  | Model 3 |  |  |
---|---|---|---|---|---|---|---|---|---|---|---|
 | HR | 95% CI | P value |  | HR | 95% CI | P value |  | HR | 95% CI | P value |
MACEa | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
SHR index | 1.89 | 1.54–2.32 | < 0.001 |  | 1.85 | 1.50–2.27 | < 0.001 |  | 1.86 | 1.51–2.30 | < 0.001 |
SHR1 | 1.09 | 0.82–1.44 | 0.562 |  | 1.09 | 0.83–1.45 | 0.531 |  | 1.07 | 0.81–1.42 | 0.634 |
SHR2 | Reference | Â | Â | Â | Reference | Â | Â | Â | Reference | Â | Â |
SHR3 | 1.98 | 1.53–2.56 | < 0.001 |  | 1.94 | 1.50–2.51 | < 0.001 |  | 1.92 | 1.48–2.49 | < 0.001 |
All-cause Mortalityb | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
SHR index | 2.31 | 1.87–2.87 | < 0.001 |  | 2.25 | 1.81–2.79 | < 0.001 |  | 2.20 | 1.76–2.77 | < 0.001 |
SHR1 | 0.93 | 0.68–1.29 | 0.679 |  | 0.94 | 0.68–1.29 | 0.686 |  | 1.05 | 0.75–1.46 | 0.787 |
SHR2 | Reference | Â | Â | Â | Reference | Â | Â | Â | Reference | Â | Â |
SHR3 | 2.17 | 1.64–2.86 | < 0.001 |  | 2.11 | 1.59–2.79 | < 0.001 |  | 2.19 | 1.64–2.93 | < 0.001 |
Cardiovascular Mortalityc | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
SHR index | 2.55 | 2.00-3.25 | < 0.001 |  | 2.49 | 1.95–3.18 | < 0.001 |  | 2.48 | 1.92–3.20 | < 0.001 |
SHR1 | 1.13 | 0.77–1.68 | 0.529 |  | 1.14 | 0.77–1.68 | 0.517 |  | 1.18 | 0.79–1.77 | 0.409 |
SHR2 | Reference | Â | Â | Â | Reference | Â | Â | Â | Reference | Â | Â |
SHR3 | 2.71 | 1.93–3.81 | < 0.001 |  | 2.65 | 1.88–3.73 | < 0.001 |  | 2.70 | 1.90–3.83 | < 0.001 |