Fig. 4
From: Direct regulation of the cardiac ryanodine receptor (RyR2) by O-GlcNAcylation
Effect of Thm-G and CaMKII inhibition on the characteristics of SOICR. Representative CEPIA traces for (A) KN-92 treated cells, cells treated with (B) KN-93, (C) Thm-G + KN-92 and (D) Thm-G + KN-93. Scale bar shows fluorescence (10AU) vs. time (60s). (E) Comparison of FSOICR, and (F) fractional release between treatments. Data were obtained from 156–542 cells recorded over 6–14 independent experiments. Results are expressed as Mean ± SEM. Statistical analysis was performed using a two-way ANOVA (with Fisher’s LSD post-hoc test)