Fig. 3
From: Direct regulation of the cardiac ryanodine receptor (RyR2) by O-GlcNAcylation
CaMKII inhibition does not prevent an O-GlcNAc mediated increase SOICR propensity. (A-C) Representative Fluo-4 traces (F/F0) of cells treated with KN-92 or KN-93 in the absence (A) or presence of Thm-G (B) or DON (C). Peaks represent SOICR events. (D-F) Percentage of cells experiencing SOICR treated with KN-92 or KN-93 in the absence (D) or presence of Thm-G (E) or DON (F). Data displayed are the average of 4–12 independent experiments and expressed as Mean ± SEM. P-values shown are for comparison of cells treated with KN-92 vs. KN-93. Statistical analysis was performed using two-way ANOVA (with Šidák post-hoc test)