Microvesicle-associated and circulating microRNAs in diabetic dyslipidemia: miR-218, miR-132, miR-143, and miR-21, miR-122, miR-155 have biomarker potential

Table 9 Significant correlations among circulating/plasma inflammatory cytokines and miRNAs in the diabetic dyslipidemia context

T₂D-DLP group		IFNγ	TNFα	IL-1β	IL-6
Plasma miRNAs ↓	n	17	17	17	17
Plasma miR-21	r	0.251	0.941	− 0.884	− 0.352
Plasma miR-21	P	0.682	0.013	0.052	0.563
Plasma miR-34a	r	− 0.111	0.962	− 0.580	− 0.711
Plasma miR-34a	P	0.854	0.010	0.302	0.174
Plasma miR-132	r	0.252	0.781	− 0.311	− 0.332
Plasma miR-132	P	0.680	0.122	0.612	0.584
Plasma miR-143	r	0.091	− 0.200	0.283	− 0.412
Plasma miR-143	P	0.880	0.751	0.651	0.480
Plasma miR-223	r	− 0.312	− 0.894	0.913	0.201
Plasma miR-223	P	0.600	0.042	0.034	0.742
Plasma miR-122	r	0.033	− 0.280	0.623	− 0.504
Plasma miR-122	P	0.962	0.643	0.262	0.383
Plasma miR-126	r	0.721	0.282	− 0.453	0.042
Plasma miR-126	P	0.160	0.641	0.441	0.951
Plasma miR-155	r	− 0.421	− 0.784	0.892	0.152
Plasma miR-155	P	0.421	0.124	0.040	0.801
Plasma miR-200b	r	0.252	− 0.572	0.412	0.822
Plasma miR-200b	P	0.671	0.314	0.491	0.083
Plasma miR-212	r	0.620	0.681	− 0.322	− 0.532
Plasma miR-212	P	0.262	0.210	0.594	0.363
Plasma miR-218	r	0.100	0.452	− 0.462	− 0.564
Plasma miR-218	P	0.871	0.441	0.431	0.322

Spearman rank correlation test was used to assess relationships among variables. Bolded coefficients show a powerful correlation, and of them only italic underlined coefficients are significant (p < 0.05)

ISSN: 1475-2840