Microvesicle-associated and circulating microRNAs in diabetic dyslipidemia: miR-218, miR-132, miR-143, and miR-21, miR-122, miR-155 have biomarker potential

Nemecz, Miruna; Stefan, Diana Simona; Comarița, Ioana Karla; Constantin, Alina; Tanko, Gabriela; Guja, Cristian; Georgescu, Adriana

doi:10.1186/s12933-023-01988-0

Cardiovascular Diabetology

Table 8 Significant correlations among circulating/plasma miRNAs and relevant clinical parameters in the diabetic dyslipidemia context

From: Microvesicle-associated and circulating microRNAs in diabetic dyslipidemia: miR-218, miR-132, miR-143, and miR-21, miR-122, miR-155 have biomarker potential

T₂D-DLP group		miR-21	miR-34a	miR-132	miR-143	miR-223	miR-122	miR-126	miR-155	miR-200b	miR-212	miR-218
Clinical measurements ↓	n	17	17	17	17	17	17	17	17	17	17	17
TC	r	− 0.052	− 0.154	− 0.691	0.324	0.061	0.021	0.030	− 0.052	− 0.451	− 0.340	0.441
TC	P	0.931	0.803	0.192	0.592	0.921	0.973	0.961	0.933	0.441	0.572	0.463
HDL-c	r	0.293	0.462	0.821	− 0.201	− 0.254	0.074	0.051	− 0.132	0.112	0.574	− 0.171
HDL-c	P	0.642	0.441	0.080	0.742	0.683	0.902	0.942	0.831	0.851	0.314	0.783
LDL-c	r	0.431	− 0.122	− 0.292	0.300	− 0.512	− 0.131	0.902	− 0.711	− 0.233	0.411	0.612
LDL-c	P	0.461	0.840	0.630	0.613	0.381	0.842	0.031	0.170	0.704	0.490	0.270
TG	r	− 0.511	− 0.55	− 0.592	− 0.312	0.442	− 0.381	− 0.494	0.451	0.432	− 0.931	− 0.451
TG	P	0.372	0.332	0.291	0.600	0.452	0.523	0.394	0.443	0.492	0.023	0.442
TGO	r	− 0.492	− 0.521	− 0.380	− 0.552	0.404	− 0.540	− 0.562	0.472	0.631	− 0.945	− 0.680
TGO	P	0.401	0.360	0.522	0.330	0.502	0.342	0.323	0.421	0.252	0.012	0.212
TGP	r	0.402	− 0.153	0.090	− 0.112	− 0.514	− 0.380	0.781	− 0.632	0.264	0.391	0.140
TGP	P	0.501	0.810	0.881	0.850	0.374	0.531	0.123	0.251	0.670	0.512	0.821
Fasting glucose	r	0.430	0.131	0.540	− 0.781	− 0.542	− 0.840	0.171	− 0.444	0.551	0.040	− 0.410
Fasting glucose	P	0.473	0.832	0.343	0.120	0.354	0.071	0.774	0.462	0.342	0.943	0.493
HbA1c	r	− 0.311	− 0.540	− 0.500	0.802	0.312	0.720	0.612	0.061	− 0.050	0.381	0.380
HbA1c	P	0.600	0.341	0.363	0.100	0.614	0.170	0.271	0.920	0.931	0.520	0.524
Haemoglobin	r	− 0.423	− 0.460	0.070	− 0.753	0.311	− 0.584	− 0.462	0.423	0.962	− 0.652	− 0.940
Haemoglobin	P	0.481	0.432	0.904	0.140	0.614	0.302	0.431	0.471	0.004	0.230	0.012
Creatinine	r	− 0.010	− 0.170	0.170	− 0.893	− 0.101	− 0.900	− 0.312	0.030	0.733	− 0.594	− 0.710
Creatinine	P	0.984	0.783	0.784	0.040	0.874	0.034	0.604	0.961	0.161	0.292	0.173
Urea	r	− 0.180	− 0.370	− 0.340	− 0.5631	0.084	− 0.712	− 0.303	0.112	0.464	− 0.781	− 0.440
Urea	P	0.772	0.541	0.583	0.320	0.903	0.174	0.620	0.850	0.433	0.110	0.451
Uric acid	r	0.620	− 0.580	− 0.880	0.293	0.621	0.202	− 0.340	0.531	− 0.21	− 0.713	− 0.020
Uric acid	P	0.261	0.304	0.054	0.633	0.263	0.741	0.572	0.360	0.972	0.172	0.962
Erythrocytes	r	0.521	− 0.591	− 0.950	0.493	0.512	0.302	− 0.016	0.350	− 0.154	− 0.511	0.210
Erythrocytes	P	0.372	0.290	0.010	0.401	0.380	0.621	0.920	0.562	0.802	0.382	0.734
Platelets	r	0.850	0.701	0.390	0.340	− 0.800	0.123	0.712	− 0.860	− 0.780	0.910	0.844
Platelets	P	0.063	0.184	0.514	0.571	0.100	0.851	0.180	0.061	0.121	0.030	0.072
Leucocytes	r	0.371	0.084	0.563	− 0.370	− 0.451	− 0.364	0.463	− 0.432	0.450	0.451	− 0.200
Leucocytes	P	0.543	0.901	0.324	0.534	0.440	0.541	0.430	0.463	0.453	0.440	0.743
Monocytes	r	− 0.190	0.342	0.013	0.260	0.334	0.474	− 0.594	0.422	− 0.502	− 0.132	0.122
Monocytes	P	0.754	0.574	0.992	0.674	0.593	0.423	0.292	0.473	0.381	0.840	0.851
SBP	r	− 0.831	− 0.752	− 0.514	0.510	0.830	0.714	− 0.061	0.701	0.370	− 0.153	− 0.233
SBP	P	0.084	0.140	0.372	0.384	0.083	0.182	0.922	0.192	0.543	0.804	0.711
DBP	r	0.064	− 0.053	0.262	− 0.942	− 0.174	− 0.931	− 0.362	− 0.011	0.662	− 0.554	− 0.702
DBP	P	0.921	0.932	0.664	0.014	0.782	0.020	0.553	0.980	0.221	0.333	0.191

Spearman rank correlation test was used to assess relationships among variables. Bolded coefficients show a powerful correlation, and of them only italic underlined coefficients are significant (p<0.05)

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