Microvesicle-associated and circulating microRNAs in diabetic dyslipidemia: miR-218, miR-132, miR-143, and miR-21, miR-122, miR-155 have biomarker potential

Table 7 Significant correlations among microvesicle-associated microRNAs (MV miRNAs) and circulating/plasma MVs in the diabetic dyslipidemia context

T₂D-DLP group		ErMVs	PMVs	LeMVs	MMVs	EMVs	Total MVs
MV miRNAs ↓	n	17	17	17	17	17	17
MV miR-21	r	0.461	− 0.012	0.100	0.430	0.261	0.603
MV miR-21	P	0.422	0.981	0.874	0.461	0.673	0.271
MV miR-34a	r	− 0.024	0.291	− 0.263	− 0.053	0.152	− 0.822
MV miR-34a	P	0.973	0.630	0.662	0.922	0.793	0.081
MV miR-132	r	− 0.791	− 0.403	− 0.273	0.580	− 0.492	− 0.600
MV miR-132	P	0.100	0.494	0.642	0.292	0.393	0.271
MV miR143	r	− 0.751	− 0.613	0.221	− 0.190	− 0.651	− 0.470
MV miR143	P	0.140	0.262	0.71	0.752	0.224	0.412
MV miR-223	r	− 0.162	− 0.110	− 0.590	0.603	0.051	− 0.130
MV miR-223	P	0.780	0.852	0.281	0.281	0.934	0.833
MV miR-122	r	− 0.401	− 0.480	0.672	− 0.683	− 0.552	− 0.040
MV miR-122	P	0.503	0.404	0.211	0.202	0.330	0.941
MV miR-126	r	0.720	0.863	− 0.330	− 0.124	0.761	− 0.390
MV miR-126	P	0.161	0.050	0.581	0.842	0.133	0.503
MV miR-155	r	0.173	− 0.284	0.693	− 0.514	− 0.182	0.971
MV miR-155	P	0.783	0.633	0.193	0.372	0.75	0.012
MV miR-200b	r	0.394	0.751	− 0.754	0.313	0.671	− 0.841
MV miR-200b	P	0.500	0.133	0.132	0.601	0.212	0.072
MV miR-212	r	− 0.351	− 0.780	0.740	− 0.711	− 0.620	0.552
MV miR-212	P	0.553	0.112	0.143	0.170	0.262	0.331
MV miR-218	r	− 0.944	− 0.631	0.121	0.392	− 0.770	− 0.330
MV miR-218	P	0.014	0.241	0.844	0.510	0.124	0.571

Spearman rank correlation test was used to assess relationships among variables. Bolded coefficients show a powerful correlation, and of them only italic underlined coefficients are significant (p < 0.05)

ISSN: 1475-2840