Microvesicle-associated and circulating microRNAs in diabetic dyslipidemia: miR-218, miR-132, miR-143, and miR-21, miR-122, miR-155 have biomarker potential

Table 6 Significant correlations among microvesicle-associated microRNAs and circulating/plasma inflammatory cytokines in the diabetic dyslipidemia context

T₂D-DLP group		IFNγ	TNFα	IL-1β	IL-6
MV miRNAs ↓	n	17	17	17	17
MV miR-21	r	− 0.591	0.234	− 0.541	− 0.351
MV miR-21	P	0.292	0.701	0.342	0.551
MV miR-34a	r	0.383	− 0.090	− 0.141	0.092
MV miR-34a	P	0.521	0.871	0.161	0.604
MV miR-132	r	0.530	0.474	0.822	− 0.204
MV miR-132	P	0.341	0.414	0.811	0.873
MV miR143	r	− 0.090	0.311	0.280	− 0.330
MV miR143	P	0.881	0.602	0.631	0.571
MV miR-223	r	0.370	0.791	− 0.921	− 0.070
MV miR-223	P	0.531	0.103	0.020	0.902
MV miR-122	r	− 0.540	− 0.221	− 0.662	− 0.270
MV miR-122	P	0.342	0.710	0.220	0.651
MV miR-126	r	0.311	− 0.502	0.683	− 0.123
MV miR-126	P	0.602	0.390	0.203	0.833
MV miR-155	r	− 0.803	− 0.301	− 0.192	0.161
MV miR-155	P	0.091	0.612	0.741	0.790
MV miR-200b	r	0.742	− 0.011	0.384	− 0.202
MV miR-200b	P	0.141	0.980	0.524	0.741
MV miR-212	r	− 0.924	0.183	− 0.151	− 0.330
MV miR-212	P	0.021	0.772	0.801	0.583
MV miR-218	r	0.261	0.242	0.011	0.254
MV miR-218	P	0.671	0.691	0.980	0.681

Spearman rank correlation test was used to assess relationships among variables. Bolded coefficients show a powerful correlation, and of them only italic underlined coefficients are significant (p < 0.05)

ISSN: 1475-2840