Microvesicle-associated and circulating microRNAs in diabetic dyslipidemia: miR-218, miR-132, miR-143, and miR-21, miR-122, miR-155 have biomarker potential

Nemecz, Miruna; Stefan, Diana Simona; Comarița, Ioana Karla; Constantin, Alina; Tanko, Gabriela; Guja, Cristian; Georgescu, Adriana

doi:10.1186/s12933-023-01988-0

Cardiovascular Diabetology

Table 5 Significant correlations among microvesicle-associated microRNAs and relevant clinical parameters in the diabetic dyslipidemia context

From: Microvesicle-associated and circulating microRNAs in diabetic dyslipidemia: miR-218, miR-132, miR-143, and miR-21, miR-122, miR-155 have biomarker potential

T₂D-DLP group		MV miR-21	MV miR-34a	MV miR-132	MV miR-143	MV miR-223	MV miR-122	MV miR-126	MV miR-155	MV miR-200b	MV miR-212	MV miR-218
Clinical measurements ↓	n	17	17	17	17	17	17	17	17	17	17	17
TC	r	0.901	− 0.751	− 0.861	− 0.711	0.012	− 0.271	− 0.091	0.881	− 0.531	0.4002	− 0.771
TC	P	0.031	0.144	0.050	0.171	0.991	0.650	0.882	0.040	0.352	0.494	0.123
HDL-c	r	− 0.692	0.753	0.831	0.752	0.150	0.254	0.051	− 0.902	0.531	− 0.292	0.661
HDL-c	P	0.181	0.141	0.072	0.133	0.800	0.681	0.920	0.032	0.322	0.634	0.212
LDL-c	r	0.331	− 0.470	− 0.182	− 0.821	0.631	− 0.992	0.064	0.011	0.183	− 0.562	− 0.434
LDL-c	P	0.570	0.412	0.762	0.080	0.251	0.0014	0.910	0.974	0.764	0.321	0.464
TG	r	0.272	− 0.624	− 0.471	− 0.321	− 0.372	0.142	− 0.301	0.853	− 0.762	0.440	− 0.133
TG	P	0.651	0.252	0.412	0.583	0.531	0.811	0.620	0.062	0.134	0.440	0.822
TGO	r	0.022	− 0.522	− 0.190	− 0.120	− 0.334	0.213	− 0.414	0.681	− 0.753	0.404	0.161
TGO	P	0.972	0.363	0.754	0.831	0.571	0.723	0.492	0.194	0.144	0.502	0.790
TGP	r	− 0.242	− 0.191	0.370	− 0.421	0.624	− 0.831	− 0.050	− 0.371	0.301	− 0.740	0.151
TGP	P	0.681	0.751	0.52	0.471	0.251	0.081	0.932	0.522	0.611	0.142	0.790
Fasting Glucose	r	− 0.431	− 0.221	0.771	0.172	0.570	− 0.322	− 0.600	− 0.292	− 0.152	− 0.223	0.750
Fasting Glucose	P	0.451	0.722	0.124	0.770	0.300	0.580	0.273	0.631	0.804	0.721	0.140
HbA1c	r	− 0.191	0.430	− 0.302	− 0.493	− 0.222	− 0.361	0.913	− 0.382	0.823	− 0.821	− 0.512
HbA1c	P	0.752	0.463	0.614	0.391	0.711	0.542	0.021	0.513	0.082	0.082	0.373
Hemoglobin	r	− 0.620	− 0.021	0.422	0.282	− 0.260	0.281	− 0.323	0.031	− 0.322	0.014	0.681
Hemoglobin	P	0.263	0.962	0.471	0.642	0.662	0.642	0.591	0.963	0.591	0.992	0.190
Creatinine	r	− 0.252	− 0.471	0.402	0.111	0.150	0.010	− 0.704	0.261	− 0.620	0.194	0.621
Creatinine	P	0.683	0.420	0.502	0.850	0.803	0.991	0.182	0.672	0.251	0.742	0.2503
Urea	r	0.221	− 0.782	− 0.181	− 0.323	0.010	− 0.102	− 0.573	0.734	− 0.810	0.350	0.080
Urea	P	0.714	0.112	0.762	0.594	0.981	0.862	0.304	0.151	0.090	0.553	0.881
Uric acid	r	0.522	− 0.433	− 0.890	− 0.521	− 0.560	0.141	0.172	0.852	− 0.462	0.360	− 0.60
Uric acid	P	0.364	0.461	0.042	0.362	0.320	0.821	0.780	0.060	0.420	0.543	0.234
Erythrocytes	r	0.592	− 0.440	− 0.950	− 0.720	− 0.422	− 0.100	0.303	0.770	− 0.292	0.160	− 0.180
Erythrocytes	P	0.281	0.441	0.012	0.162	0.470	0.862	0.611	0.122	0.630	0.794	0.092
Platelets	r	0.360	− 0.034	0.133	− 0.142	0.761	− 0.560	− 0.023	− 0.350	0.353	− 0.211	− 0.230
Platelets	P	0.540	0.942	0.821	0.810	0.131	0.312	0.961	0.552	0.554	0.722	0.700
Leucocytes	r	− 0.691	0.272	0.833	0.203	0.484	− 0.370	− 0.100	− 0.760	0.444	− 0.664	0.653
Leucocytes	P	0.192	0.653	0.073	0.731	0.412	0.534	0.870	0.131	0.451	0.224	0.231
Monocytes	r	0.353	0.210	− 0.371	0.390	− 0.454	0.702	0.091	0.273	− 0.172	0.683	− 0.250
Monocytes	r	0.551	0.721	0.533	0.512	0.442	0.184	0.88	0.654	0.771	0.192	0.671
SBP	r	− 0.492	0.654	− 0.264	− 0.071	− 0.781	0.284	0.870	− 0.253	0.582	− 0.490	− 0.210
SBP	P	0.401	0.232	0.662	0.911	0.110	0.642	0.053	0.674	0.291	0.390	0.731
DBP	r	− 0.220	− 0.473	0.441	0.190	0.200	0.041	− 0.781	0.254	− 0.660	0.281	0.672
DBP	P	0.713	0.421	0.440	0.752	0.741	0.941	0.112	0.673	0.213	0.640	0.21

Spearman rank correlation test was used to assess relationships among variables. Bolded coefficients show a powerful correlation, and of them only italic underlined coefficients are significant (p < 0.05)

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