Microvesicle-associated and circulating microRNAs in diabetic dyslipidemia: miR-218, miR-132, miR-143, and miR-21, miR-122, miR-155 have biomarker potential

Nemecz, Miruna; Stefan, Diana Simona; Comarița, Ioana Karla; Constantin, Alina; Tanko, Gabriela; Guja, Cristian; Georgescu, Adriana

doi:10.1186/s12933-023-01988-0

Cardiovascular Diabetology

Table 3 Significant correlations among circulating/plasma MVs and relevant clinical parameters in the diabetic dyslipidemia context

From: Microvesicle-associated and circulating microRNAs in diabetic dyslipidemia: miR-218, miR-132, miR-143, and miR-21, miR-122, miR-155 have biomarker potential

T₂D-DLP group		ErMVs	PMVs	LeMVs	MMVs	EMVs	Total MVs
Clinical measurements ↓	n	17	17	17	17	17	17
TC	r	0.552	0.094	0.300	− 0.421	0.255	0.822
TC	P	0.332	0.880	0.613	0.463	0.674	0.081
HDL-c	r	− 0.484	− 0.102	− 0.442	0.302	− 0.163	− 0.911
HDL-c	P	0.413	0.863	0.451	0.624	0.791	0.030
LDL-c	r	0.493	0.553	− 0.632	0.624	0.614	0.101
LDL-c	P	0.394	0.334	0.252	0.262	0.272	0.873
TG	r	− 0.053	− 0.313	0.812	− 0.261	− 0.380	0.924
TG	P	0.933	0.603	0.091	0.672	0.521	0.022
TGO	r	− 0.314	− 0.453	0.820	− 0.093	− 0.583	0.801
TGO	P	0.605	0.441	0.080	0.873	0.302	0.103
TGP	r	0.013	0.350	− 0.643	0.964	0.261	− 0.201
TGP	P	0.985	0.560	0.244	0.013	0.663	0.742
Fasting Glucose	r	− 0.703	− 0.391	− 0.164	0.811	− 0.494	− 0.100
Fasting Glucose	P	0.184	0.512	0.793	0.094	0.392	0.871
HbA1c	r	0.761	0.983	− 0.564	0.222	0.870	− 0.382
HbA1c	P	0.134	0.014	0.313	0.711	0.052	0.524
Hemoglobin	r	− 0.652	− 0.433	0.512	0.323	− 0.691	0.212
Hemoglobin	P	0.224	0.464	0.372	0.593	0.193	0.733
Creatinine	r	− 0.702	− 0.624	0.464	0.402	− 0.75	0.440
Creatinine	P	0.170	0.262	0.432	0.503	0.142	0.450
Urea	r	− 0.261	− 0.433	0.633	0.083	− 0.494	0.861
Urea	P	0.663	0.461	0.251	0.894	0.392	0.053
Uric acid	r	0.483	0.114	0.631	− 0.582	0.111	0.814
Uric acid	P	0.403	0.851	0.240	0.293	0.853	0.092
Erythrocytes	r	0.693	0.352	0.394	− 0.452	0.371	0.731
Erythrocytes	P	0.192	0.560	0.513	0.431	0.533	0.152
Platelets	r	0.253	0.252	− 0.803	0.242	0.484	− 0.443
Platelets	P	0.672	0.670	0.094	0.692	0.400	0.454
Leucocytes	r	− 0.422	0.063	− 0.583	0.911	− 0.071	− 0.601
Leucocytes	P	0.470	0.912	0.302	0.030	0.892	0.272
Monocytes	r	0.091	− 0.251	0.421	− 0.940	− 0.091	− 0.051
Monocytes	P	0.874	0.682	0.482	0.011	0.873	0.920
SBP	r	0.423	0.624	0.021	− 0.122	0.393	− 0.250
SBP	P	0.474	0.261	0.960	0.833	0.502	0.681
DBP	r	− 0.773	− 0.710	0.470	0.363	− 0.811	0.422
DBP	P	0.124	0.171	0.421	0.554	0.092	0.474

Spearman rank correlation test was used to assess relationships among variables. Bolded coefficients show a powerful correlation, and of them only italic underlined coefficients are significant (p < 0.05)

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